The Clinical And Experiment Research Of Rheumatoid One Treatment Of Active Rheumatoid Arthritis

Objective This subject include three parts.â‘ Theoriest part,I learn formed form TCM classic theories and my tutor get the knowledge that as "hidden-pathogens causing rheumatism doctrine"â‘¡Clinical part, systematic evaluate and compare the therapeutic efficacy of Rheumatoid one in treating activated arthritis to evaluate the clinical effect and drug-using security.â‘¢Experiment research,we using the serum of RA patient,testing the level of JAK-STAT proteins and some factors of NEI network,then to observe the effect of Rheumatoid one to them,in order to provide the basis of the mechanism of this drug worked on arthritis.Methodsâ‘ Theoriest part, by collectting the TCM classic theories,we found the origin theory of the knowledge "hidden-pathogens causing rheumatism doctrine".â‘¡Clinic Part:By American College Rheumatology(ACR)standard classification of2009for diagnosis basis.Ninety patients of RA were randomly divided into two group.The treatment group treated with Rheumatoid one Combined With Tripterygium wilfordii while the control group only treated withTripterygium wilfordii. The treatment of12weeks was observed in the Patients with the difference of ACR and DAS28to evaluated its clinical efficacy.Main outcome measures:include tender joint count,swellon joints count,pain joint count,visual analogue scale test,time of morning stiffness(min),hand grip strength (mmHg) and ESR,CRP,RF,a-CCP, PLT,RBC,WBC,HGB,ALT,AST.â‘¢Experiment research:we choose forty patients whose disease at the activity time, then randomly divided the forty patients into two groups as the treatment group which treated with Rheumatoid one Combined With Tripterygium wilfordii while the control group only treated with Tripterygium wilfordii. Using ELIS A method for the determination of serum JAK1,STAT3,IL-6, IL-21,SP,PRL.The observe time is twelve weeks. Meanwhile, we choose twenty healthy people as controls,. observe the change of six indexes in the serum,and compare the after-treating indexes with the before-treating in activity RA.Resultsâ‘ Theoriest part, We think that main pathology mechanism of RA in periods of activity is low-speel function, damp-heat and stasis-toxicant obstructing channels and flowing to limbs joints. We work form complex way and large amount of the medicine making the drug called Rheumatoid one.â‘¡Clinic Part:after treatment for3months, the treatment group got a better overall assessment, The total effective rate of DAS28is93.3%,all patients got ACR20,77.8%patients got ACR50and42.22%patients got ACR70.Signs and symptoms aspect:Rheumatoid one play a good role not only on relieve the pain and swelling, morning stiffness, grip strength, pain VAS score and patient overall health status and also show at blood indicators:ESR, CRP, RF and a-CCP have varying degrees of decline after treatment. Meanwhile Rheumatoid one have low adverse effects, no adverse effects of combination therapy superposition.â‘¢Experiment research:the serum of JAK1,STAT3,IL-6,IL-21,SP, PRL which owed by activity RA is higher than healthy ones.After treatment,both groups make these factors low in different extent,and the group with Rheumatoid one get more obvious low in IL-6,JAK1,STAT3and SP.Conclusion Rheumatoid one is an origin theory based on my tearchers academic thought; It can significantly alleviate the clinical symptoms of patients, significantly reduce laboratory index,and have less adverse reaction;Being activity RA,the JAK-STAT load and NEI network is being actived, Rheumatoid one can partially inhibit the activation of JAK-STAT protein and NEI network factor.