| Objective:To Organize, summarize ZENGD Deng-lun’s Academic Origin, academic thought and clinical experience in the treatment of internal diseases. Research on "fair reinforcing the spleen and kidney method" on the functional status of patients with malignant tumors (KPS) score, the impact of Treg cells and Foxp3 expression to evaluate the process of the patients’immune function in tumor cells, clinical experience provided by its scientific scientific evidence, provide a theoretical basis for the clinical treatment of malignant tumors. Method:By reviewing instructor school experience, professional growth process, academic thought process to explore the formation of teacher Academic Origin. Key summarize, organize teacher had given Lun internal diseases academic thought and clinical experience, put forward their own perception of learning with the teacher and instructor since experience to explore and experience, and discussed by typical medical records, analysis and verification. London has given the teachers were " fair reinforcing the spleen and kidney method " in advanced cancer patients KPS, clinical study of cell immune function. Randomized controlled method, were included in the stationary phase Ⅳ of patients with malignant clear pathological diagnosis of 80 cases (including 40 cases of lung cancer, colon cancer and 40 cases) were randomly divided into treatment group and control group 40 cases (of which 20 cases of lung cancer, colon cancer 20 cases), based on clinical symptoms in both groups support the use of Western medicine therapy based treatment group use of reinforcing spleen recipe on the basis of oral law. The control group was thymopentin intramuscular injection, treatment lasted a month. Comparison of two groups of patients before and after treatment KPS score changes, the use of flow cytometry to detect the two groups of patients before and after treatment of peripheral blood CD4+ CD25+ Foxp3+ T cell number and percentage of CD4+ T cells using real-time quantitative polymerase chain The reaction (Real-time PCR) to detect transcription factor Foxp3 mRNA expression.Results:By exploring Zeng teacher academic origins, exploring the name of the Chinese medicine experts in the Road to Success for students to follow the footsteps teachers continue to Qihuang road trek the direction. Teacher to "via" is based on the original proposed "wind pathogenesis of stroke within originated in the "Yellow Emperor", "split the positive "within the virtual product damage" caused by a stroke after the reference point of the Tang and Song began, academic history of Chinese medicine for stroke be revised. According to Chinese medicine miscellaneous diverse etiology, pathogenesis complex, longer duration, slow onset characteristics, teacher advocates "miscellaneous miscellaneous diseases need treatment," and proposed to supplementation and attack, both exterior and interior, cold and heat and use, lifting simultaneously, blood Tongzhi and a method for the treatment of miscellaneous diseases basic law. For difficult diseases, has given London teacher advocates Executive Jane Yu Fan, TCM Perpetual concept as a guide, pay attention to air-lift access, by restoring the physiological function of the spleen and stomach drop to achieve conditioning Cardinal recovery purposes the body’s normal physiological function. Pay attention to the teacher in the four diagnostic inquiry, advocated four diagnostic parameters, advocated tongue, pulse and patients to know to understand the syndrome often, of its change. For traditional Chinese medicine, ideology, he advocated diagnosis and treatment, the first re sensible, Liming the law legislation, the law established the prescription. He believes that the basic mechanism is to seize the key link Treating the disease, and patient advocates emphasis on identification of physical and diseases and syndromes combined. For the treatment of cough cough teacher proposition when the site to identify the depth of the disease bit different treatments have also been separately; for "yin yang micro strings" Chest of TCM, the teacher asked, "Yang micro non inevitable, overcast chord is the main reason, " the view of "phlegm, stasis" argument, advocates focus on "Bi" word, the "real evil heart vessel blockage, no pain" as the basic pathogenesis, based on phlegm, blood stasis pass Treating Chest. Teacher advocate for stroke treatment stage of governance, the acute phase of liver wind, phlegm, blood stasis based, may be appropriate to Tongfu by evil; he advocated promoting blood circulation, meridians treatment should be run through the entire treatment of ischemic stroke always; importance and salty insects Tongluo drug application in clinical medicine, advocated Smart Ching, caution AIDS tired, warm dry obstruct fill, fill astringent. Treat stomach diseases, teachers believe that the air-lift disorders is the basic pathogenesis of gastrointestinal disease, to "Acrid bitter drop" as the basic treatment of gastrointestinal disease treatment method, the use of "BanxiaxiexinTang" for the treatment of gastrointestinal disease represented party. Oral disease is a common disease, frequently-occurring disease, according to the teacher Bayu Region gasification environment and people’s eating habits characteristics, establishing "Yin hot potato" pathogenesis, treatment with "heat dampness, purging fire detoxification" wonderful in "Raising Yin and moistening, sour and sweet Yin, acid convergence muscle ", take the analogy like to take the drugs to cure skin" skin "for the treatment of disease characteristics. The teacher also advocated early cancer also complement, also late attack, attack and make up, mainly through detailed clinical syndrome, a clear decision after pathogen relations within the patient’s body. He proposed "spleen deficiency-oriented, Phlegm, blood stasis, heat intrinsic toxicity is labeled" malignant TCM "in order to fill the main intermittent Quxie" treatment principle, the method he advocates the use of fill unbiased heat and cold, fair spleen and kidneys, and the method throughout the stages of cancer treatment. Clinical study of part of the treatment group and the control group, a total of 65 cases of final completion of the course of treatment, both groups showed two groups of patients before treatment, functional status (KPS) score of Treg cells accounted for the percentage of CD4+ cells and peripheral Foxp3 transcription factor mRNA expression no significant difference (P>0.05), comparable. After treatment, the former KPS score with this group before treatment and after treatment were significantly higher in the control group, the difference was significant (P<0.05); after treatment of Treg cells among CD4+ before the percentage of cells compared with the present treatment group and the control group after treatment, significantly reduced, a significant difference (P<0.01). After treatment, peripheral blood and significantly lower in this group after treatment than before treatment and control group, the mRNA expression of Foxp3 transcription factor, the difference was significant (P<0.01). Conclusion:Zeng Teacher ground seeking old sayin, familiar classics, ancient division no mud in the ancient, clinical thought the ancient physicians, the theory of its own clinical practice critical understanding, Ancient Literature, integration of new knowledge, the treatment of difficult miscellaneous diseases formed its own characteristics, treatment ideas and The method is worth further organize, summarize, inheritance, carry forward. "fair reinforcing the spleen and kidney method " can significantly improve the functional status of patients with malignant tumors (KPS) score, can significantly reduce the proportion of Treg cells in CD4+T cells, and confirmed that the effect may be to reduce the expression of Foxp3 mRNA transcription factor to achieve. |
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