Study Of The Clinical Effect Of "Yiqi Huoxue Decoction" On Hepatocirrhosis With Ascites In Hepatitis B

Background: Hepatocirrhosis is a commonly seen disease,which is caused by virus of hepatitis B in most cases. Ascites is its complication of endangering human life. According to a national epidemiology study of hepatitis B in 2006 ,the positive HBsAg rate was 7.18% among people under 60,from which it is estimated that,there would be 93 million people infected with HBV in our country including 20 million CHB patients.Since there are so many hepatocirrhosis patients,the result is that a geart number of hepatocirrhosis exists.At present,the effect of antivirus, diuresis and controlling the primary disease with drugs is accepted widely.While,However how to meliorate the liver function and the function of the whole body is still difficult for western medicine.Recent TCM researches hold that most patients of hepatocirrhosis with ascites in hepatitis B are suffering from qi deficiency and blood stasis.To solve the problem the formul "Yiqi Huoxue Decoction"has been developed to enhance diuresis and meliorate the liver function combined with western drugs.This research aims to analyze the curative effect of "Yiqi Huoxue Decoction" in the treatment of above .MHE was used called SHE,there is no recognized diagnosis standard.and now NCT-A and DST are commonly used to diagnose this disease.Objective: To analyze and discover the curative effect and safety of "Yiqi Huoxue Decoction" combined with Western drugs.and to find out the preponderant effect in the treatment group,and the occurrence of minimal hepatic encephalopathy(MHE) in hepatocirrhosis patients to lay a foundation for further study.Method: Clinical observations were based on random,double-blind,and parallel controlled trial.62 patients are randomly divided into the treatment group and control group, all of them are under one course of treatmen(30 days).The former who treated with "Yiqi Huoxue Decotion"combined with western drugs,while the later with western drugs and herbal placebo.The body weight,abdominal perimeter,urinary volume in 24 hours were recorded everyday in the course, The variation of symptom score, liver function grade,abdominal B ultrasonice inspection ,and the intellectuality level were recorded at the beginning and on the 14th and 30th day .The Chi-square test was used for the enumeration data and T test or tank-sum test was selected for the measurement data.Result:In the two groups there were more men than women, over 50 year old.The intellectuality level was related to age,education,but not to occupation.The treatment group had a better effect in diuresis according to the variation of body weight,abdominal perimeter,and urinary volume.There was statistical difference in ascites in the two groups tested by abdominal B ultrasonice inspection(P<0.01).But,the contrast of function between the two groups showed no statistical difference.The tendency chart indicated difference in AST,TBIL,PTA,(0-14th day)and ALT(15-30th day), GGT AKP(0-30th day) of the two groups.The melioration was better in the treatment group.There was no statistical difference in the intellectuality level between the two groups.The variation of symptom score,such as pain in abdomen, abdominal distention,no appetite, tiredness,less talking, loose stools, had a statistical difference ( P<0.01 ) ,and the safety of "Yiqi Huoxue Decoction" was proved.Conclusion: The combined therapy of "Yiqi Huoxue Decoction" and Western drugs has advantages in dieresis and relieve the symptoms of qi deficiency and blood stasis in comparison with Western drugs only.Although there is no statistical difference in meliorating the liver function,while it shows in the tendency chart that the conbined therapy is effective in specific time.There is potential advantage of "Yiqi Huoxue Decoction" in meliorating the liver function.and the decotion is safe without side effect.