| Research backgroundIschemic disease (ischaemic renal disease, IN) is because the renal artery, renal artery of the main branches and before the glomerular capillary at various levels as a result of the blood vessel damage artery chronic kidney tissues ischemic injury, is causing end-stage renal disease (end stage renal diseases, ESRD) one of the most important reasons. The most common disease because adults renal artery stenosis (renal artery stenosis RAS), mainly including atherosclerosis renal artery stenosis, fiber muscular dysplasia, artery inflammation, etc. With the improvement of people’s living standard, people with diabetes, hypertension, atherosclerosis of patients is growing and the incidence of ischemic kidney disease also improved obviously, leading to the fatality rate of ESRD also improved obviously, average life period significantly shortened, so IN recent years IN receiving more and more attention.At present IN the cause of ESRD because treatment means more localized, can only rely on dialysis or a kidney transplant treatment, and long-term dialysis or a kidney transplant, will give the patient and family to bring huge burden, require huge financial, human and material resources. But there is no IN the pathogenesis of a thorough understanding of the studies that show and of renin-angiotensin system activation, of tubulointerstitium inflammatory cells infiltration, kidney cells turn into muscle inherent fibroblasts (myofibroblast, Myo-FB), and other factors. If can make clear understanding of IN pathogenesis, and according to the pathogenesis give a specific therapy, delay IN development for the progress of ESRD, and will be of great significance IN patients.At present, the domestic research for of IN far behind on the cardiovascular disease and cerebrovascular disease research, whether IN basic research, clinical research and treatment or reports and documents do less, the home also not to the diagnosis of IN treatment guidelines, more not targeted drug treatment. And traditional Chinese medicine in control of kidney disease field an irreplaceable role, so the purpose of this study is to observe yiqi, dredging party of kidney to ischemic intervention function and mechanism. For Chinese medicine control to provide treatment methods and ischemic nephropathy ideas.Research objectsTo research the action of Oral medicine combined with Western medicine study of early ischemic renal oral creatinine, urea nitrogen and renal arterial blood vessels.To establishment of early ischemic nephropathy diagnosis and treatment of clinical medicine integrative medicine program to explore the Chinese Yiqihuoxue collaterals treatment of early ischemic nephropathy new way.Research methodChosen for the early diagnosis of ischemic renal disease, TCM is Qi and Blood60 patients were randomly divided into treatment group and control group,30patients. Treated with conventional western medicine, oral Yiqihuoxue meridians of Chinese medicine decoction treatment; control group with conventional western medicine. Observed before and after treatment of clinical symptoms, renal artery and creatinine, urea nitrogen, and to explore traditional Chinese medicine treatment Yiqihuoxue collaterals in patients with early ischemic renal efficacy and mechanism of action.Research results1.Clinical efficacy:The treatment group total effective rate was84%, significantly higher than that of control group72%(p<0.05).2. Symptoms of traditional Chinese medicine curative effect:The two groups were can effectively improve the symptoms of traditional Chinese medicine TCM syndrome integral, reduction,(p<0.05) treatment group in improving fatigue, shortness of breath, lazy word, Yaoxisuanruan, dizziness symptoms of traditional Chinese medicine in terms of efficacy were mostly better than the control group (p<0.05)3. Group therapy in reducing microalbuminuria has better effect than the control group(p <0.05), The two groups had no significant effect on renal function (p>0.05)Research conclusionsYiqi Tongluo Decoction on early ischemic nephropathy(Qi deficiency and blood stasis type) has obvious curative effect, the method can remarkably reduce urinary albumin, effective improvement in fatigue, fatigue, lumbar acid, dizziness and other symptoms, and no obvious side effects.After oral administration of losartan potassium in treatment of early ischemic nephropathy (Qi deficiency and blood stasis type)based on the use of Yiqi Tongluo decoction combined treatment, has good synergistic effect, can significantly improve the efficacy, high cure rate, worthy of further clinical study.Yiqi Huoxue Tongluo can be used as a treatment for early ischemic nephropathy (Qi deficiency and blood stasis type)often method, modification according to symptoms, dialectical application, can get satisfactory effect. |
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