Research And Application Of Preeclampsia/eclampsia Based On Bibliometric Analysis

Research backgroundIn the research field of preeclampsia / eclampsia,since ancient times,from domestic to foreign countries,the researchers wrote a lot of books and literature,the research achievements and experiences of carrying their clinical research.In the face of the rapid growth of massive medical literature,if the traditional manual retrieval methods have been unable to accurately and timely capture the dynamic development of the subject,then the method objectively requires a new,scientific,efficient,accurate and intuitive knowledge,to reveal the structure and evolution process of the subject.The solution of conventional bibliometric "sorting" and "extreme" problem,it is difficult to solve the data exists in the "structure" and other issues,such as massive data in the literature,the author of perplexing inter agency cooperation relations,research theme,structure and evolution of research in the field of potential development trend.Other issues;and the data graphic is not based on statistical performance of the internal mechanism of statistical data,statistical data can not meet on multidimensional performance and analysis requirements.How can we study numerous predecessors from the mass of data found in the scientific research,summed up the law,a new prospect in the field and in an intuitive display forms and other issues need to solve every research worker.The emergence of bibliometric analysis is to meet the needs of science and the development of the times.It can deep mining of multiple disciplines including medicine research frontier and hotspot in information visualization,knowledge map form,more effective and more intuitive to reveal the internal relations of medical research and the important information hidden,provides a new method for research focus and frontier development for researchers grasp the medicine.Part I Study on the external structure of preeclampsia / eclampsia based on Bibliometric Analysis ObjectiveThis study used quantitative and qualitative chapters,combining theory with practice,the theory of bibliometrics for preeclampsia research,systematically research cooperation of relevant agencies and the author,reveals the development venation of the field,and the research unit subject influential figures to find the core,trying to accurately and clearly to reveal the knowledge structure.It is of great practical significance for us to choose and follow the frontiers of science and technology research and development,and to explore and develop the strategy and policy of science and technology.In this study,assistive technology researchers,to grasp the present situation of the world's authoritative database of preeclampsia / eclampsia research field,provide information on many aspects for the personnel of scientific research work;to provide reference data for the future scientific management decision;provides new direction for the domestic and foreign academic exchanges and cooperation between the.In order to make the management of scientific research personnel and technical staff to gain a better understanding of the scientific research cooperation necessity and importance,but also better for the study of preeclampsia to provide a scientific basis,and thus more effective to prevention and treatment of preeclampsia.Material method 1 data sources and processingIn this study,we selected the web of core collection database,that is,SCI-EXPANDED,CCR-EXPANDED,Index Chemicus in the relevant data as a source of literature.2 research toolsIn this study,Citespace software is selected as a research tool.Citespace is mainly used to analyze the knowledge inflection point,the research hotspot,the evolution path,the knowledge structure and the new trend.By using the dynamic,diachronic and diversified information visualization technology,a dynamic knowledge map is constructed,which is based on the citation age of colored ribbon table and the time line.3 literature analysis methodThe main analysis methods of this study are: 1 Boolean logic analysis method;2 parameter setting time from 2007-2016,each time segment(time slice)is set for 1 years,threshold selection each time the first 50 high cited documents,namely Top 50;3 analysis methods of link strength;4 maximum expected value(EM)analysis methods;5 of the modular analysis method;6 frequency analysis;7 citation analysis;8 cluster analysis;analysis of 9 common words;10 visualization methods;11 mutation analysis of 12 word monitoring;LLR analysis;13 knowledge map analysis method;14 society network analysis method.Research resultsFrom 2007 to 2016,a total of 5608 literatures on the study of preeclampsia / eclampsia were retrieved,and the literature in the field of pre eclampsia was observed to increase steadily.The main types of preeclampsia is published articles,followed by review and conference abstracts,the United States became the preeclampsia / eclampsia article cited the country with the highest level,followed by Britain,Holland,Canada and other countries,Chinese ranked sixth.Scientific research institutions is ranked first in Canada of British Columbia University,cited the number of magazines is the highest An International Journal of Obstetrics and Gynaecology,followed by Obstetrics Gynaecology and Lancet.Sibai BM,Roberts JM,Duley L is the most influential in the field of the three researchers.Conclusion(1)it is found that the field of pre eclampsia / eclampsia has been developing steadily and has been paid more and more attention.The main types of publications are papers.(2)Sibai BM is the most cited author.(3)the United States has become the most cited country in the field of preeclampsia / eclampsia.(4)Columbia University,Canada,is one of the most productive research institutions in the field.(5)An International of Obstetrics and Gynaecology is the most cited periodical in the Journal.(6)obstetrics and gynecology is the main research direction of literature distribution.Part II A study on the hotspot and frontier of preeclampsia / eclampsia based on Bibliometric Analysis ObjectiveThis chapter studies the method of qualitative analysis and quantitative analysis,combining theory with practice,the theory of literature metrology research for preeclampsia / eclampsia,by exploring the field of high cited keywords and key documents,combined with time series analysis to accurately and clearly reveal the knowledge structure,the research found frontier,research hotspots and development trend.Strive to make scientific research managers and technical staff to better understand the necessity and importance of scientific research cooperation,better grasp the important research direction in this field.Material method 1 data sources and processingIn this study,we selected the web of core collection database,that is,SCI-EXPANDED,CCR-EXPANDED,Index Chemicus in the relevant data as a source of literature.2 research toolsIn this study,Citespace software is selected as a research tool.Citespace is mainly used to analyze the knowledge inflection point,the research hotspot,the evolution path,the knowledge structure and the new trend.By using the dynamic,diachronic and diversified information visualization technology,a dynamic knowledge map is constructed,which is based on the citation age of colored ribbon table and the time line.3 literature analysis methodThe main analysis methods of this study are: 1 Boolean logic analysis method;2 parameter setting time from 2007-2016,each time segment(time slice)is set for 1 years,threshold selection each time the first 50 high cited documents,namely Top 50;3 analysis methods of link strength;4 maximum expected value(EM)analysis methods;5 of the modular analysis method;6 frequency analysis;7 citation analysis;8 cluster analysis;analysis of 9 common words;10 visualization methods;11 mutation analysis of 12 word monitoring;LLR analysis;13 contour value(Silhouette)analysis method;14 knowledge map analysis method;15 society network analysis method.Research results(1)Through the bibliometric analysis found that preeclampsia / 7 main research direction in the field of eclampsia,namely: endothelial growth factor,angiogenesis study research,preeclampsia / eclampsia epidemiological studies,hemodynamic studies,Doppler ultrasound research,cardiovascular disease research,study on the relationship between eclampsia and convulsions.(2)The study on the hemodynamic changes of preeclampsia / eclampsia is the most popular research at present,and the study of maternal natriuretic peptide and serum biomarkers are the most advanced research.(3)The most active hot spots in the field of pre eclampsia and eclampsia are: the study of biomarkers,the study of complications,and the analysis of(Meta).Conclusion 1 The main 7.research directions in the field of pre eclampsia / eclampsia were found by bibliometric analysis.2 The study of hemodynamic changes in preeclampsia / eclampsia is one of the hottest research topics.3 The most active hot spots are: biomarker research,complications,and Meta analysis.Part III Two photon microscopy was used to observe the changes of cerebral blood flow and cerebral blood flow in mice ObjectiveThrough the quantitative analysis of second pre eclampsia / eclampsia,we can conclude that the study on the hemodynamic changes of preeclampsia / eclampsia is one of the most popular research directions.However,it is very important to explore the influence of the changes of cerebral vascular environment on the nervous system diseases such as preeclampsia and eclampsia.Therefore,the purpose of this study is to investigate the dynamic changes of the cerebral blood flow and the diameter of cerebral vessels in the pre pregnancy to late pregnancy.Material methodGet 12 adult female mice from Guangzhou Zhongshan Medical University Experimental Animal Center(weight 20-22 g,10-12 weeks),divided into the following groups: non pregnancy group(n = 3),pregnancy group(n = 3),the second trimester group(n = 3),late pregnancy group(n = 3).Remove most skin to expose the skull brain for cranial window imaging,with 1.5% three bromoethanol anesthetized mice,imaging in at least 15 minutes before injection intraperitoneally in mice 0.1ml rhodamine B isothiocyanate dextran solution fluorescence labeling.The mice were then placed on the head holder.The mice were placed on the pad,and the body temperature was maintained at 37 C.Line scan parameters are recorded automatically in ZEN software.MatLab program can calculate the velocity of red blood cell(RBC)in cerebral blood vessels according to the linear scanning parameters.Measurement of vessel diameter by Image J software.Single factor analysis of variance(ANOVA)was used to compare the mean values between different groups,and the values were expressed as the mean + SE,and P <0.05 was statistically significant.Result1 and non pregnancy group(4.14 + 0.51 mm / s)and early pregnancy group(4.21 + 0.47)compared to the speed of pregnancy group arteriovenous blood medium significantly increased(4.54 + 0.44 mm / mm / s)(P <0.05);the speed of blood flow in arteriovenous vascular late pregnancy group(5.44 + 0.70 mm / s)was significantly higher than non pregnant group,early pregnancy group and mid pregnancy group(P <0.05).Late pregnancy group(0.48 + 0.07 mm / s)capillary velocity was also significantly higher than the non pregnancy group(0.33 + 0.06 mm / s),early pregnancy group(0.34 + 0.03 mm / s)and mid pregnancy group(0.37 + 0.07 mm / s)(P <0.05).2 mid pregnancy group(32.36 + 1.82 m)and late pregnancy group(35.88 + 3.64 m)diameter of artery and vein than the non pregnancy group(29.05 + 3.13 u m),the early pregnancy group(30.29 + 2.18 m)vein diameter were significantly increased(P <0.05),the late pregnancy group vascular diameter is larger than the mid pregnancy group(P <0.05).With the non pregnancy group(4.01 + 0.62 m)and early pregnancy group(4.31 + 0.64 m)compared to mid pregnancy group(5.02 + 0.67 m)and late pregnancy group(5.55 + 0.82 m)significantly increased the capillary diameter(P <0.05).Conclusion(1)the blood flow velocity of the arteries,veins and capillaries in the late pregnancy and the second trimester was significantly higher than that in the non pregnancy and early pregnancy.(2)the diameter of the vessels and capillaries in the late pregnancy and the second trimester was significantly higher than that in the non pregnancy and early pregnancy.Research innovation1 the first study of preeclampsia / eclampsia was carried out by bibliometric analysis.2(1)by bibliometric analysis found that preeclampsia / 7 main research direction in the field of eclampsia,namely: endothelial growth factor,angiogenesis study research,preeclampsia / eclampsia epidemiological studies,hemodynamic studies,Doppler ultrasound research,cardiovascular disease research,the relationship between eclampsia and convulsions study.(2)the study of the hemodynamic changes of preeclampsia / eclampsia is the most popular research,and the research of maternal natriuretic peptide and serum biomarkers are the most advanced research.(3)to explore the most active hot spots in the field of pre eclampsia / eclampsia: the study of biomarkers,the study of complications,and the analysis of Meta.3 For the first time,the brain blood flow and cerebral blood vessels of mice were analyzed by two photon microscopy.4 The blood flow velocity of the blood vessels and capillaries in the late pregnancy and the second trimester was significantly higher than that in the non pregnancy and early pregnancy.5 Compared with non pregnancy and early pregnancy,the vascular diameter of late pregnancy and mid pregnancy was significantly higher than that of non pregnancy and early pregnancy.