Design,Preparation,and Biological Application Of Biomimetic Intelligent Polymer Hydrogel Materials

In order to meet people's increasingly application needs,smart hydrogels have become the forefront of polymer science due to their superior properties.With the efforts of scientific researchers,the performance of smart hydrogels has been greatly improved,and the scope of application has been continuously explored.Even so,mo st smart hydrogels lack biological functions and are difficult to solve practical problems in biomedicine.How to endow the gel multiple functions while making it have biological properties is a problem that needs to be solved in the practical application of hydrogels.In nature,the shape,pattern and structure of organisms provide inspiration for scientific innovation,and also provide a valuable reference for solving the problems that smart hydrogels face in biological applications.From the perspective of basic research and practical application,it is of great practical significance to explore new types of hydrogels with biological application functions.Therefore,this paper takes smart hydrogels as the main line,draws on bionics thinking,and aims to solve practical problems in biological applications.First,inspired by the structure of animal bone matrix,we constructed an inorganic-organic composite scaffold to assist stem cells in the treatment of rheumatoid arthritis.The composite scaffold material combines a three-dimensionally printed porous metal scaffold with a polysaccharide self-healing hydrogel.The introduction of hydrogel can not only deliver bone marrow mesenchymal stem cells to the targeted site,but also provide a favorable three-dimensional microenvironment for the cells functions.This structural and functionally optimized composite scaffold makes full use of the advantages of inorganic and organic materials to more realistically simulate the physical and chemical environment of the bone matrix.After carrying bone marrow mesenchymal stem cells,the composite scaffold has the function of inhibiting inflammatory factors,rebuilding damaged cartilage,and promoting subchondral bone regeneration.Secondly,we used rheumatoid arthritis commonly used drugs and chemically modified polysaccharides as the main raw materials to further construct a hydrogel with anti-inflammatory function.Under the action of this hydrogel,the survival and osteogenic differentiation of adipose-derived mesenchymal stem cells have been greatly improved.The results of cell and animal experiments show that the antiinflammatory hydrogel composite scaffold play a role in inhibiting inflammatory factors and rebuilding bone tissue in the improvement of rheumatoid arthritis.Afterwards,we further developed a biomimetic mineralized hydrogel,inspired by the mineralization process in the biological world.The mineralized hydrogel uses nano-hydroxyapatite,sodium carbonate and polyacrylic acid as raw materials,and forms a three-dimensional network structure through supramolecular self-assembly.The mineralized hydrogel is similar in microstructure and chemical composition to natural bone tissue.It is worth noting that under physiological conditions,mineralized hydrogels have good stability,biocompatibility,biological activity,and osteoconductivity.Without the introduction of exogenous stem cells,the hydrogel itself can promote the regeneration of bone defects in osteoporosis.Finally,inspired by the multifunctionality of animal skin,a multifunctional conductive hydrogel with antibacterial activity was constructed.The polydopaminemodified silver nanoparticles,polyaniline,and polyvinyl alcohol supramolecules selfassemble into a three-dimensional three-dimensional polymer network.The conductive hydrogel has a wide range of adjustable mechanical properties,attractive processing properties,self-healing properties,multiple adhesions,and broad-spectrum antibacterial activity that traditional conductive hydrogels do not possess.This conductive hydrogel can be used as an epidermal sensor to monitor the large-scale movement of the human body and the reflection status of animals in real time.In addition,in the treatment of diabetic foot wounds,the hydrogel has the effects of promoting blood vessel and collagen production,inhibiting bacterial growth,and controlling wound infections.