Based On The Theory Of "Kidney Deficiency,Water-dampness And Blood Stasis",a Research For A Chinese And Western Medicine Optimization Plan To Delay The Progress Of Chronic Kidney Disease (CKD3)

ObjectiveBased on the theory of "kidney deficiency?water-dampness and blood stasis ",To evaluate the efficacy and safety of Chinese medicine granules on the patients of chronic kidney disease(CKD3 period).The Chinese medicine formula granule has the function of "tonify renal,Clear the hot and humid and activate blood".In the end,to form a optimization plan of Chinese and western medicine for chronic kidney disease(CKD3)which can be clinical practice.MethodsWe did a multicenter,double-blind,randomized,placebo-controlled clinical trial in patients with CKD stage 3 from 9 hospitals.Patients in CM group self-administered Chinese herbal granules twice daily for 24 weeks,while patients in control received masked granules.All patients continued the routine therapy such as low-protein diet,control of blood pressure and so on.24-hour urine total protein(UTP),serum creatinine(Scr)and eGFR were analyzed at week 24.ResultsBetween April 2014 and Oct 2016,a total of 343 randomised patients were treated and 343 patients(171 in CM group versus 172 in control)were eligible for the full analysis set.Overall,at 24 weeks there was no statistical difference in UTP between the two groups(0.97±1.14g/d versus 0.97±1.25g/d).The levels of Scr in CM group decreased significantly compared with the control(130.78±32.55?mol/L versus 149.12±41.27?mol/L).eGFR in CM group remained stable while in control eGFR reduced statistically(55.74±50.82 ml/min/1.73m2 versus 44.46±12.60ml/min/1.73m2).There were 4.35%patients with stage 3a CKD in CM group progressed to stage 3b,and 57.97%reverse to stage 1 or stage 2,while that in control was 20.59%and 17.65%.There were 9.21%patients with stage 3b CKD in CM group progressed to stage 4,and 40.79%reverse to stage 1 or 2 or 3a,while that in control was 17.11%and 22.37%.The total effective rate of the treatment group was 72.93%,the control group was 34.69%,and the difference between the two groups was statistically significant(P<0.05).ConclusionOur data indicated that Chinese herbal compound combined with routine therapy maintains the kidney function in patients with stage 3 CKD for 24 weeks.Chinese herbal granules With the function of "tonify renal,Clear the hot and humid and activate blood " can maintain the renal function level stablely serum in 24 weeks in patients with chronic kidney disease(CKD)stage 3,The optimization plan of Chinese and western medicine for chronic kidney disease(CKD3)can delay the progress of renal function to a certain extent,with reliable efficacy and safety,suitable for clinical promotion.