| Abstract 1 The efficacy and safety of dabigatran on the elderly with non-valvular atrial fibrillation[Objective]We aimed to evaluate the efficacy and safety of dabigatran on the elderly with non-valvular atrial fibrillation(NVAF).[Methods]100 Consecutive old patients with NVAF who received dabigatran 110mg bid in our Hospital from September 2015 to April 2017 were enrolled.Demographics,clinical characteristics of these patients were collected.The adverse events at follow up were collected.According to whether there was bleeding or not,the patients were divided into two groups.The differences between the two groups were analyzed.[Results]The mean age of patients was 72.72±7.10 years.55 out of the patients were male.The average CHADS2 score was3.61±1.48,and the average HASBLED score wasl.95±0.81.The mean follow-up time was 6.87 + 4.06 months.No patient suffered ischemic stroke,transient ischemic attack,systematic thromboembolism,myocardial infarction,and re-hospitalization.No patient suffered major bleeding.18 patients suffered minor bleeding(18%).CHADS2 score was higher in the bleeding event group(P=0.077).A high proportion of ACEI drugs were taken(P=0.033).The proportion of ARB drugs taken was low(P=0.011).A high proportion of digoxin was taken at the same time(P=0.018).Serum albumin levels were low(P=0.039).Patients suffering minor bleeding had a prolonged prothrombin time(P=0.026).decreased prothrombin activity(P=0.001)?elevated INR(P=0.039)?prolonged activated partial thromboplastin time(P<0.001)?prolonged thrombin time(P<0.001)and increased serum albumin level(P=0.028).[Conclusions]This study showed that Dabigatran 110mg twice one day used for the senior patients with NVAF with low risk of stroke and massive hemorrhage,and the incidence of minor hemorrhage is 18%.Combined use of digoxin and low serum albumin levels can lead to increased risk of bleeding.Abstract 2 Association of soluble ST2 and Galectin-3 with New Onset Atrial Fibrillation After Ventricular Septal Myectomy in Patients with Hypertrophic Cardiomyopathy[Objective]We aimed to explore the association between soluble ST2 and galectin-3(Gal-3)levels and new onset atrial fibrillation after ventricular septal myectomy in patients with hypertrophic cardiomyopathy(HCM).[Methods]170 Consecutive HCM patients who underwent ventricular septal myectomy in our Hospital from 2011 to 2016 were enrolled.Demographics,clinical characteristics and echocardiographic parameters of these patients were collected.Soluble ST2 and Gal-3 levels were examined by Enzyme-linked immunosorbent assay(ELISA).The association of these parameters with new onset postoperative atrial fibrillation(POAF)were assessed.[Results]POAF was documented in 16 patients in hospital.POAF patients were older(49.8 ± 9.6 vs.42.1 ± 14.2years,P=0.036)and had more smoking(62.5%vs.38.3%,P=0.047).Soluble ST-2[9.0(7.3-22.2)vs.12.6(8.7-18.0)ng/ml,P=0.37]and Gal-3[7.2(6.2-9.9)vs.7.1(5.4-8.7)ng/ml,P=0.45]in patients with POAF were similar to that in those without POAF.In multivariable regression analysis,age(odds ratio 1.065,95%confidence interval 1.007 to 1.126,p=0.028)was an independent predictor of POAF.[Conclusions]Plasma soluble ST-2 and Gal-3 levels were not associated with the occurrence of POAF in patient with HCM who underwent ventricular septal myectomy.Advanced age might be an independent predictor of POAF in HCM patients after surgical ventricular septal myectomy. |
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