Prof.Sun Wei's Theory Of Protecting Kidney And Delaying The Aging Of Senile And The Clinical Practice Of Patients With Kidney Deficiency Syndrome In Taiwan

Objective:To explore Professor Sun Wei's understanding of the theory of medicine in the theory of solidifying kidney and delaying inflammation.To use Professor Sun Wei's theory of solid kidney delay in the clinical treatment of Taiwan kidney yang deficiency syndrome,kidney yin deficiency syndrome and kidney qi deficiency syndrome,especially its impact on clinical symptoms,inflammatory factors,immune levels and other methods,and evaluates its safety,providing an objective basis for clinical application.Method:(1)Theoretical analysis.Analyze the understanding of the kidneys by Chinese medicine,the physiological functions of the kidneys,the relationship with different tissues and organs,and the causes,pathogenesis and syndrome differentiation of kidney deficiency syndrome by means of review the materials and read the relevant books;(2)Professor Sun Wei's theory of solid kidney delay.Introduce the basic situation of Professor Sun Wei,the theoretical basis of the kidney-retaining and the application of clinical evidence;Analyze the common Chinese medicine based on Professor Sun Wei's theory of solid kidney delay;(3)Professor Sun Wei's clinical practice of solid kidney failure theory.Randomized and controlled research methods were used to select 98 patients with kidney yang deficiency syndrome and kidney yin deficiency syndrome with chronic glomerulonephritis or diabetes from March 2015 to March 2018.Divide the patients into observation group and control group with every 49 patients,according to random number table.The control group received symptomatic supportive treatment by routine western medicine therapy.On the basis of routine western medicine therapy,the observation group added with Professor Sun Wei's theory of solid kidney delay,and was given herbal soup for 3 months(1 course).The efficacy was assessed according to the change of clinical symptoms,renal function levels,inflammatory factors,immune levels,and also its safety.All data were processed by SPSS 24.0 software.Results:(1)The TCM syndrome scores of both group at 1 month,2 months and 3 months after treatment were lower than that before the treatment(P<0.05);And the 3-month TCM syndrome scores of the observation group were lower than the control group(P<0.05);Three months after the treatment,five upset heat or backache,soft knees,fine pulse,red tongue,less phlegm,oropharyngeal dryness,String dizziness,tinnitus,bone steaming hot flashes,hot flashes,night sweats,insomnia,forgetfulness,body weight loss,loose teeth,less refined,premature ejaculation,nocturnal emission,menstrual or amenorrhea score of the observation group,were lower than before treatment(P<0.05).Three months after treatment,cold,cold limbs,loss of libido or soft waist,delayed pulse,weak pulse,pale tongue,white,mental weakness,shortness of breath,lower extremity edema,hair decay or nocturnal urinary frequency symptoms score of the observation group,were lower than before treatment(P<0.05);After 3 months treatment,shortness of breath,fatigue,weakness or backache,soft complexion,pale complexion,insufficient veins,pale tongue,moss white,urinary residual leaching,nocturia,urinary incontinence,premature ejaculation,slippery essence or decontamination scores of patients from observed group with kidney qi deficiency,were lower than before treatment(P<0.05);(2)The treatment effective rate of Professor Sun Wei in the observation group was 93.88%after 3 months of treatment,which was higher than that of the control group(85.71%,P<0.05).(3)The levels of BUN,Scr and 24h UP from both grouo were lower than before(P<0.05).The levels of BUN,Scr and 24h UP from the observation group were lower than that from the control group after 3 months treatment(P<0.05).(4)The levels of TNF-a,IL-6 and hs-CRP from both group after 3 months treatment were lower than before(P<0.05).The NO level from both group after 3 months treatment was higher than before(P<0.05);The levels of TNF-a,IL-6 and hs-CRP from the observation group were lower than that from the control group after 3 months treatment(P<0.05).The NO level from the observation group was higher than that in the control group after 3 months treatment(P<0.05);(5)CD3?,CD4+,CD4+/CD8+from the observation group were higher than that from the control group(P<0.05).The level of CD8+from the observation group was lower than that from the control group(P<0.05).There was no significant difference in the incidence of nausea and vomiting,diarrhea,rash and allergy between the observation group and the control group(P>0.05).Conclusion:(1)Through theoretical analysis,Professor Sun Wei's theory of solid kidney delay has certain scientific and theoretical basis,and the drug selection is scientific;(2)Result from the preliminary clinical research,Professor Sun Wei's theory of solid kidney delay used in Taiwan patients with kidney yang deficiency syndrome,kidney yin deficiency syndrome and kidney qi deficiency syndrome to improve the clinical symptom score,reduce the level of inflammatory factors,improve the body's immune level,and the drug safety is high.It may provide new ideas and methods for the treatment of kidney yang deficiency syndrome,kidney yin deficiency syndrome and kidney qi deficiency syndrome.