Study On The Correlation Between The Ultrasonic Parameters Of Urethral Geometry And Baldder Obstruction In Patients With LUTS/BPH

Objective:Study on the correlation between the ultrasonic parameters of urethral geometry and bladder obstruction in patients with LUTS/BPH,which could provide further clinical proof of diagnosis and treatment.Materials and methods:1.Retrospective analysis: We collected 120,000 BPH outpatients then we randomly stratified 2001 patients according to age.All the patients completed the IPSS questionnaire and TRUS.R 3.2.5 was used for statistical analysis of the correlation between the parameters and age.2.Retrospective analysis: 643 patients between January 2014 and December 2016 who were diagnosed as LUTS/BPH were collected.We used R 3.2.5 statistical software to finish the data analysis.The linear regression models were established to evaluate the relationship between the measurements and age.3.Establishment of the ordinal regression model: We established ordinal regression models using the data set of the first part（2001 patients）to screen the meaningful parameters.4.Prospective study: 73 patients from June 2017 to March 2018 who were diagnosed as BPH were involved.The multivariate ordinal regression model were verified.Then we made ROC curves between BOO and ultrasonic parameters.Results:V_TP,V_TZ,TZI,IPP,Lp and WTZ were closely related to age.The TZ grows in a highest rate during 50-69 yr.In addition,we found that as men aging,TZI changed in different prostate volumes.Lppu,Hppua had a linear relationship with IPSS/Qo L,especially with v IPSS.The optimal ordinal regression model was: score Agebands + IPP + Lppu+ Hppua.This model can be used to correct the retrospective errors of patients’ history recall and to assist in further clinical diagnosis and treatment.Lppu,Hppua and IPP can be used as comprehensive indicators for the diagnosis and evaluation of LUTS/BPH,forecasting prostatic urethral geometry change and judging whether patients with obstruction or not.Conclusion:These results suggested that TZ grows the fatest during the progress of BPH.Lppu,Hppua,IPP can be used to determine whether patients with obstruction or not and help clinical doctors select optimal treatments.