| Amorphous solids or organic glasses have found applications in food, pharmaceuticals, and organic electronics. In pharmaceutical science, amorphous formulations are used to overcome the poor solubility and slow dissolution of a growing number of new drug candidates. In electronics, the lack of grain boundary and tunable orientation of organic molecules in the glassy state allows for better light emission and charge transfer.;This dissertation is devoted to engineer organic glasses to tailor for their applications. In the first area, amorphous formulations can extend its shelf life by preventing it from crystallization. Fast surface crystallization has been identified as the major cause of instability. A novel gelatin nano-coating method has been applied to amorphous drug surfaces to inhibit its fast surface crystallization. With this technology, drug loading can be increased while freeing up other excipients for optimizing other aspects of product performance. In the second area, for the first time, a liquid crystal (LC) transition has been supercooled to form glasses with different LC order, providing a molecular understanding of liquid crystalline phase formation. This work suggests a general condition for preparing anisotropic organic glasses with tunable liquid crystalline order for electronic applications. |
