| In a separate line of transgenic mice, I examine the role of CREB-family transcription factors in striatum-dependent habit learning. I find a deficit in habit learning, but no deficit in hippocampus-dependent spatial learning in these mice. These data represent the first examination of striatum-dependent learning in genetically modified mice, to my knowledge. Together, my findings support a shared role for CREB-family transcription factors in declarative and procedural learning factors in striatum-dependent habit learning. I find a deficit in habit learning, but no deficit in hippocampus-dependent spatial learning in these mice. These data represent the first examination of striatum-dependent learning in genetically modified mice, to my knowledge. Together, my findings support a shared role for CREB-family transcription factors in declarative and procedural learning. |
