| ene regulation in cells infected with HSV, a double-stranded DNA containing virus, can be divided into three temporally regulated phases, termed ;From these results, a model is favored where newly synthesized virus proteins (at least ICP4) modify and/or interact with preexisting host factors to alter the binding properties of complexes that form between these cell proteins and the downstream region adjacent to the TK promoter.;Poliovirus contains a single-stranded, 7.5 kb RNA genome of positive polarity which includes 5;In this dissertation, I demonstrate the ICP4 is a component of a complex formed between a sequence downstream from and adjacent to the promoter for the thymidine kinase (TK) gene (a prototype of the... |
