Anticancer and antimalarial agents from Thai medicinal plants

During the course of the investigation of the cytotoxic and antimalarial potential of the tubers of Stephania erecta Craib, fourteen alkaloids were isolated. These alkaloids included the bisbenzylisoquinolines (+)-cepharanthine, (+)-2-norcepharanthine, (+)-obaberine, (+)-2-norobaberine, (+)-homoaromoline, (+)-stephibaberine, (+)-daphnandrine, (+)-isotetrandrine, (+)-2-norisotetrandrine, (+)-thalrugosine, (+)-2-northalrugosine, (+)-2-N-methyltelobine, and (+)-1,2-dehydrotelobine, and the quaternary tetrahydroprotoberberine alkaloid (;From the bulbs of Crinum amabile Donn., two new compounds, namely, (;Phytochemical and biological investigations of the tubers of S. pierrei Diels led to the isolation of twenty-three isoquinoline alkaloids. The isolates were comprised of the aporphine alkaloids (...