| umor cell metastasis is a multifunctional process, the successful completion of which requires distinct but coordinated responses by the tumor cells to both their own internal stimuli, and external stimuli presented by the host. Tumor cells arrest is a critical event in hematogenous metastasis. Following arrest and adhesion to endothelial cells, tumor cells induce endothelial cell retraction and migrate to the subendothelial matrix. Platelets rapidly associate with the arrested tumor cells but disappear soon after tumor cell contact with the subendothelial matrix is completed.;All the aforementioned events are mediated by receptors on the surface of the tumor cell, platelet, and endothelial cell. Receptors for a number of molecules have been identified on the surface of tumor cells, and are believed to mediate tumor cell attachment to endothelial cells and subendothelial matrix. I have identified a tumor cell glycoprotein receptor (tumor cell ;The lipoxygenase metabolite of arachidonic acid, 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) is demonstrated to increase the surface expression of the tumor cell... |
