Congenital Thrombophilia In East-Asian Venous Thromboembolism Population,A Meta-Analysis And Systematic Review

Background:Venous thromboembolism(VTE)is a complex,episodic disorder worldwide.Thrombophilia is an abnormality of blood coagulation that increases the risk of thrombosis.The prevalence of thrombophilia in VTE population vary across different regions and population.Here,we performed a systematic review and meta-analysis of congenital thrombophilia in East-Asian VTE population.Methods:Publications from PubMed&EMBASE before January 1st,2019 were searched by two researchers.Studies from Japan,Korea,China,Hong Kong,Taiwan,Singapore,Thailand,Vietnam,Myanmar,and Cambodia were included.Congenital thrombophilia is described as diseases including protein C(PC)deficiency,protein S(PS)deficiency,antithrombin(AT)deficiency,factor V Leiden(FVL)and prothrombin G2021OA mutation.Studies were selected by two reviewers for methodological quality analysis.A random-effect model was used for meta-analysis.Results:Thirty studies were assessed.The prevalence of 1)PC deficiency was 12.2%,(95%confidence interval(CI):9-16,I squared=89.9%)in 2107 patients across 20 studies.2)PS deficiency was 15.1%(95%CI:11-20,I squared=88.8%)in 1887 patients across 18 studies.3)AT deficiency was 5.2%(95%CI:4-7,I squared=55.1%)in 2103 patients across 19 studies.Among 1424 patients from 16 studies,4 patients were reported as carriers of FVL mutation.Among 807 patients from 9 studies,none of the patients were carriers of prothrombin G2021OA mutation.Conclusion:The prevalence of PC,PS,AT deficiency were higher in East-Asian population compared to Caucasian population.In addition to the absent of prothrombin G2021OA mutation,low frequency of FVL mutation was observed.