| Objective:Observe the clinical curative effect and security in treatment of preglycemic diabetes with irritable bowel syndrome(liver-depression and spleen-deficiency)with tong xie sijun prescription.Analysis of clinical observations,study the involved mechanism,confirm the advantages of chinese medicine treatment of the disease,providing reference value for more effective clinical treatment of this disease.Methods:The included standard 60 cases of preglycemic diabetes with irritable bowel syndrome were allocated into a treatment group and a control group randomly.The treatment group was treated with tong xie sijun prescription associated with eosinophil-lactobacillus compound tablets,while the control group got treated with eosinophil-lactobacillus compound tablets merely,each group contain thirty cases.Observe the clinical symptoms,obesity index,blood glucose index,depression scale,quality of life scale,and intestinal flora of the two groups before and after treatment,The difference of curative effect between groups was compared.Results:1.Patients were divided into treatment group and control group,30 cases respectively.By analyzing the data of age and BMI,we can know that there is no difference between the two groups,which is comparable.The symptoms and signs of the two groups were very close to each other,meeting the test requirements.2.Improvement of TCM symptoms:Through the analysis of data statistics before and after treatment between the two groups,we are informed that compared between the two groups,the treatment group shows a marked improvement of symptoms than the control group(P<0.01),nevertheless,in the control group,patient get greater improvement in their stomachache or abdominal discomfort?abdominal pain frequency?stool character?Defecate frequency and belching symptoms after the treatment(P<0.05),other indicators did't improved significantly.Compared between two groups,in the aspects including stomachache or abdominal discomfort?abdominal pain frequency?defecate frequency and belching symptoms,the treatment group improved more obvious(P<0.05).Tips:The treatment group improved all clinical symptoms,the control group improved stomachache or abdominal discomfort?abdominal pain frequency?stool character?Defecate frequency and belching symptoms merely.In stomachache or abdominal discomfort?abdominal pain frequency?defecate frequency and belching symptoms,the treatment group performed far better than the control group.3.Total score of syndrome:statistical analysis of syndrome score of patients showed that after treatment,there was a significant difference between the two groups(P<0.01).Compared with the control group,the improvement of the treatment group was more obvious,and the difference between the two groups was very significant(P<0.01).4.Blood suger related indexes:There was no significant difference between the two groups before treatment in FPG?Flns?OGTT2h blood suger and insulin resistance level(P>0.05),it grasp comparability well.There was no significant difference in fins between the two groups after treatment and before treatment(P>0.05);after treatment,the two groups improved FPG and OGTT 2H blood glucose compared with before treatment,the results were statistically significant(P<0.05),and the treatment group was better than the control group(P<0.05).5.Fatness related indexes:There was no significant difference between the two groups before treatment in BMI and waist-to-hip ratio(P>0.05),it grasp comparability well.Intra-group comparison after treatment,the treatment group's BMI and waist-to-hip ratio improved distinctly,which is statistical significance.(P<0.05).Compared with before treatment,control group were insignificant differences(P>0.05).6.The scores of IBS-SSS scale comparison:After treatment,the data of the two groups were statistically analyzed,the difference was statistically significant(P<0.05).The patients in the control group 's level?bowel habitas?the quality of life as well as total score reduction,the difference was statistically significant(P<0.05).Intra-group comparison after treatment,the treatment group was superior to control group when compared between two groups except bowel habitas(P<0.05),the clinic effectiveness of treatment group was better than that of control group.It indicated that the treatment group improved all clinical symptoms and total scores,however,the control group improved level?bowel habitas?the quality of life as well as total score merely.In clinical effect,the treatment group performed far better than the control group except bowel habitas.7.The scores of IBS-QOL scale comparison:The IBS-QOL scale was used to further assess quality of life,there was no significant difference between the two groups before treatment in the scores of IBS-QOL scale(P>0.05)After treatment,it meet the requirements of relevant treatment research.According to the statistical analysis of the data before and after treatment,the level of total scores increased in two groups(P<0.01)with more marked elevation in treatment group(P<0.05).Analysing two subgroups of IBS-QOL scales further,each scores of the treatment group improved,the difference was statistically significant(P>0.05).The patients in the control group 's behavior disorder as well as health concerns improved merely,the difference was statistically significant(P<0.01)Compared between two groups after treatment,the Improvement of behavior disorder as well as health concerns in the treatment group were superior to that in the control group,the difference was statistically significant(P<0.05),which declared that the treatment group was superior to the control group.lt indicated that the treatment group improved each scores and total scores,however,the control group improved behavior?disorder health concerns as well as total score merely,with more marked elevation in treatment group.8.Depression scale:Before the treatment,compared the score of the Hamilton depression scale between two groups,the difference was not statistically significan(P>0.05).The score of Hamilton depression scale in the treatment group were lower than that in the control group distinctly,the difference was statistically significant(P<0.05).9.Intestinal microflora comparison:the data before and after the test can be known as the following results:before treatment,the data of the two groups are comparable.After statistical analysis(P>0.05),there is clinical significance;after treatment,there is significant difference in comparison within the group,showing a certain statistical significance,after statistical analysis(P<0.01).After treatment,the difference between the two groups was significant(P<0.05).10.Curative effect contrast:In the treatment group,7 cases recovered well,significantly improved in 14 cases,improved in 7 cases,and 2 cases to be invalid,the total effective rate was 93.33%.In the control group,1 cases recovered well,significantly improved in 7 cases,improved in 10 cases,and 12 cases to be invalid,the total effective rate was 60.00%.the effectiveness compared was statistically significant(P<0.05)Conclusion:1.The combination of compound Lactobacillus acidophilus tablet and Tongxie Sijun prescription can not only reduce the blood glucose index and obesity index,but also adjust the balance of intestinal flora,relieve the syndrome of traditional Chinese medicine,and improve the anxiety,depression and quality of life of patients.Early intervention for patients with impaired glucose tolerance and irritable bowel syndrome has a significant effect,reflecting the idea of treating the disease.2.The combination of compound Lactobacillus acidophilus tablet and Tongxie Sijun prescription has synergistic effect in the treatment of glucose tolerance disorder combined with irritable bowel syndrome,especially in regulating the balance of intestinal flora,the curative effect is better than that of compound Lactobacillus acidophilus tablet alone,which has high safety and is worth popularizing. |
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