The Oxidation Behavior And In-situ SERS Study Of Isosafrole (Safrole) In Non-aqueous System

Plenty of literatures show that there is more or less safrole existed in almost all the lauraceae plants. Isomerization of safrole can afforded isosafrole-the intermediate of the effective antihypertensive agent-methyldopa. A series of fragrance, such as piperonal, vanillin, vanitrope, ethyl-vanillin, piperonal alcohol, new piperonal, ducinyl recryst and piperonyl nitrile, can be obtained from isosafrole. At present, the only technical source of piperonal synthesis in most factory is from isosafrole by chemical oxidation with the oxidising agent, such as chromium, ozone. But owning to the serious pollution, container eroding associated with chromium and the rigor reaction condition, the complicated technics, high cost from ozonolysis, the application of chemical oxidation method is limited greatly. In order to protect environment, increase yield and low the cost, many researches wish to seek for a better method to synthesize piperonal. With the development of organic electrochemisty, C=O can be obtained from C=C by electro-oxidation. But the investigation about electro-oxidation is just at the beginning, many key problems, such as yield, selectivity in practical application and the explanation of electro-oxidation mechanism in theory, are still unfathomed. So it needs to investigate more. The thesis adopt normal electrochemical method and electrochemical in -situ SERS technique to study the electro-oxidative behavior of isosafrole on Pt, token the process of isosafrole on the surface of electrode from molecular level, such as adsorption, catalyze actions from electricity or light; analyze the influencing factor to the catalyze reaction; disscuss the possible reaction mechanism, provide experimental and pure gist for optimizing electro-oxidation method. The main job is followed by:1. By cyclic voltammogram, study the electro-oxidative behavior of isosafrole on Pt; identify the two oxidation peaks potentials; study the relation of the two peaks.2. By studing the in-situ raman spectrum of isosafrole on Ptr in non-aqueous system, identify the reactive group of isosafrole at molecular level, extend the application of SERS technique in non-aqueous system and provide experimental data for explaining SERS mechancism.3. The oxidation potential of piperonal in non-aqueous system is confirmed by CV and the catalyze action from light is found from molecular level by in-situ Raman spectrum..4. By studying the oxidation behavior of isoafrole and piperonal on pt, provide experimental data for synthesizing piperonal in industry.5. Study SERS of isosafrole on Agr firstly.