| Chirality is a phenomenon that pervades the universe and keeps in closely contact with human life. Enantiomers play an important role in pharmaceuticals, biochemistry and agrochemicals, and so on. Chiral separations comprise one of the more attractive tasks of modem chemistry because of their quintessential nature of life. Before the use of a new chiral drug, the pharmacological effects and metabolic pathways for each enantiomer must be examined. Separation techniques have taken an essential role in all stages of the process because enantiomeric separation at analytical scale is required for monitoring the enantiomeric purity of chiral drug and for performing drug metabolism, phannacokinetic and clinical studies. Furthermore, as certain enantiomers represent illicit or banned substances, chiral discrimination represents also an important topic in forensic analysis and doping control. Thus the demand for analytical methods possessing high efficiency and high-resolution capability for enantiomers separation at low cost and short analysis time is increasing.So far the methods used for the analysis of chiral compounds include high-performance liquid chromatography (HPLC), gas chromatography (GC) and recently capillary electrophoresis (CE). Chiral separation is widely accomplished via the use of chromatographic methods (HPLC and GC), which required rather expensive chiral stationary phases. CE is a modern separation technique that provides rapid analysis with high efficiency and high resolution due to a use of high electric field and a variety of selective modes. CE also has some remarkable advantages, such as quick analysis with low cost, flexibility of choose of chiral selectors, environmental friendliness and so on. The use of CE for the separation of chiral compounds can be dated by the work of Gassmann et al. in 1985 with the separation of dansyl amino acid enantiomers. Since then, many researchers move their focus on this field. CE techniques have been separated a large number of chiral compounds of interest in pharmaceutical, clinical, environmental fields.As a novel inorganic functional material, the mesoporous materials have stimulated exceedingly interests in the field of heterogeneous catalysis, inorganic chemistry, and material science and so on since they were first discovered in 1992. These mesoporous materials with uniformly sized nanochannels, tunable pore size and high surface area has been a focus of recent applications for catalysts, catalytic supports, absorbents, ion exchanges and separations, removal of heavy metals. These materials are potential candidates for a variety of applications in the fields of catalysis, optical devices, photonics, sensors, separation techniques, molecularengineering, drug delivery, sorption, acoustic or electrical insulation, ultra light structure material, etc.The dissertation consist of six parts,Chapter 1, it has been reviewed systematically the importance and methods of enantioseparation by capillary zone electrophoresis (CZE) using macrocyclic antibiotics as chiral selectors.Chapter 2, the chiral selectivity of erythromycin was first examined in CZE using a fused silica capillary column. Excellent chiral separations have been achieved for four derivatives of biphenyldimethylester to the acidic antihepatitis drugs (A1-A4), respectively. The effects of various experimental factors such as chiral selector concentration and pH value, voltage and temperature, organic modifiers on enantiomeric resolution were investigated. Enantioreso-lution was improved significantly with increasing chiral selector concentration while the migration time of the analytes showed slight increase. Enantioselectivities of the chiral solutes were considerable influenced by the content of organic modifiers in running buffer.Enantiomers of two acidic chiral drugs were resolved in the first time by capillary electrophoresis (CE) using the aceteylspiramycin as a chiral selector. The influence of pH value of background electrolyte, the concentration of background electr...
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