Study On The Preparation And Quality Stardard Of Eucommia Ulmoides Oliv Granule

The hypertension is sort of disease of doing harm to health and affecting life quality. The western medicine was applied more than the Chinese traditional medicine to cure the hypertension at clinic,but the western medicine has an poisonous effect and side-effect on the body. The Chinese traditional medicine has the advantage over the western medicine and is thinked that it is the best crude medicine to cure hypertension.The prescription drug roots in (xiangdai bencao gangmu}) published science and technology publishing company of China iatrology and medicine.The main medicine of prescription are Eucommia Ulmoides Oliv and Ramulus Uncariae cum uncis and so on.The aim is that the technology and quality standard of compound preparation of Eucommia Ulmoides Oliv Granule is developed .With -pinoresinol di-O-B - D--glucopyranoside content for indicatrix, adopt signal factor method to optimize the solvent and adopt orthogonal experimental design to optimize the extraction process of Eucommia Ulmoides Oliv. The active components of Ramulus Uncariae cum uncis extracted by water and by alcohol from the routine preparations were quantitatively compared by TCL-scanning. Conditions for the extraction were studied by orthogonal experimental design as guided by the content of stachydrine present in the extract. The something distilled by alcohol was concentrated in normal pressure, and the something distilled by watei was concentrated in reduce pressure. Adopt spray drying technics to make preparation. Adopt TCL to discriminate the stachydrine. Adopt spectrophotometry method to measure the content of Chlorogenic acid in the preparation.The most proper extraction condition for Eucommia Ulmoides Oliv is using 6 times 70% ethanol to decocte the herbs for 3 times , each time for 0.5h. Ramulus Uncariae cum uncis with 70% ethanol circumfluence to abstract twice , add 70%ethanol for 8 times , abstraction hour separate for 2h , 1h. The most proper extraction condition for water decocting is using 12 times water to decocte the herbs for 3 times , each time for 1.5h.. Adopt spray-drying process to prepare dry extract powder , one-step process to pelletize. The calibration curve was linear in the range of 1-2.5 ml (r=0.9998). The average recovery of the method was 98.19% , RSD was 1.12% (n=5).The technics and methodical control of quality of compound preparation of Eucommia Ulmoides Oliv Granule are convenient and feasible , stable and credible . Pharmacodynamics experiment supply experiment foundation for clinical application.