Study On The Ultrafine Grinding Process Of Radix Notoginseng

The technology of ultrafine powder is turning up and developing in recent years, which based on special mechanical force, physical or chemical action to obtain ultrafine powder. Not changing their chemical components, it changes their surface and interface to some fancy changes. When used, ultrafine powder can come into supernormal effects exceeding general powder. Ultrafine powder plays important roles in modern industry based on its peculiar advantage and characteristics. With rapid development of modern industry and medicine science and the saturation of subject, applications of the pulverizing technology in Chinese traditional medicine are paid more attention. The preparation of Chinese traditional medicine tend to fine particle, high medicine effect and little dosage, the pulverizing technology just fit in with the demands.Panax notoginseng (burk) F.H.chen is a kind of rare Chinese traditional herbal. It is sweet in taste, mildly bitter and warm in nature. It can arrest bleeding, remove blood stasis, and relieve pain. Radix notoginseng is mainly adopted for various kinds of internal injuries and traumas in traditional prescriptions, while it has been widely adopted for cardio-cerebrovascular diseases in recent years.Using the MICROS ultrafine grinding mill, Radix notoginseng was ultrafinely grinded. Process and characteristics of ultrafine grinding and more affecting parameters to the product properties were studied in detail in this paper. In order to know about physical and chemical character of ultrafine powder, we made use of granularity, microscopic identification, scanning electron microscope, infrared spectrum and so on, to characterize the ultrafine powder and general powder of Chinese traditional medicine. The results showed that besides smash parameters such as rotating speed of the principal axis, grinding time, solid concentration and so on. In addition, surfactant appending and its quantity will also affect their superfine grinding. The experiment results showed that the average particles size minished gradually with the increasing of the rotating speed of the principal axis and prolonging of the grinding time. Whengrinded 40-50 minutes, granularity didn't change obviously. During the process of grinding, the appending of oleic acid as surfactant could help grinding and preventing particles' massing. Besides, the particles size became more and more smaller with the amount of oleic acid.The microscopic characteristics showed that granulose, catheter and calcium oxalate tissue structure could be observed clearly in the general powder, but when it was grinded, nearly all cell walls of Radix notoginseng were broken and no integrated cells existed, and available composition can be exposed well without transmura release as usual, with greatly enhanced bioavailability.SEM photograph indicateed that ultrafine powder of Radix notoginseng took on flocculent structure, it probably because medicinal materials was subjected to fierce forward extrusion and tangential shearing force during the course of superfine grinding, cells were broken, amylum, amylose and saponin etc. were dissolving-out fully.Solution speed of available composition of Chinese traditional medicine, usually relates to the degree of fineness. If degree of fineness improved, and speed raised, clinical curative effects can be greatly enhanced. In order to study the effects of degree of fineness, the test employed high efficiency liquid chromatography (HPLC) to measure and compare the dissolving-out rate of panax saponin Rbi. The result indicated that dissolving-out rate of ultrafine powder was more than that of general powder.In order to study the effect of the technology of ultrafine powder on drug efficacy, we compared the ultrafine powder and general powder of Radix notoginseng on the effect of rat's hemostasis and cruor. Results showed that the effect of hemostasis and cruor of ultrafine powder was better than of general powder.