| Hydrazidate and its ramification are strong chelating ligands, which can form complexes with many metals. These compounds have prodigious application values, such as magnetism and optical material, molecule recognize reagent, catalyse reagent, especially in biological activity aspect. And thiosemicarbazone also possess strong coordination ability, its complexes have druggery activity, such as antitumor, restraining lepra, rheumatism, impaludism, virus, smallpox. Zinc, Nickel and Cobalt are necessary elements, which is reported that they exist in the form of complex. Therefore, in this essay, we synthesized one dihydrazidate ligand and its two complexes, and one thiosemicarbazone ligand and its two complexes. The complexes were characterized by UV-Vis, fluorescence, solid fluorescence, TG-DTA, element analysis and IR spectrum and the crystal structures are determined by single crystal X-ray diffraction methods. And their bond model with CT-DNA has also been investigated, data indicates that they all are potential DNA probe and have investigated values. Thereinto, pyridine-3-carboxaldehyde thiosemicarbazone Zn(II) complex has antiviral activity, which is potential therapy druggery. Chapter one: A new unsymmetrical dihydrazidate ligand C13H11N3O2 is synthesized, and its Co(II),Zn(II) complex are synthesized by liquid method, which formula are [Zn(C13H11N3O2)2Cl2]·2H2O 1,[Co(C13H11N3O2)2Cl2(H2O)2]·2H2O 2. Complex 1 belongs to orthorhombic system, space group Pmn21,with unit cell parameters: a = 28.58(2)A|°, b = 6.118(5)A|°, c = 7.762(6)A|°, Z = 2, final R1 = 0.0670, wR2 = 0.1504(I>2 σ(I)), while complex 2 belongs to monoclinic system, space group P21/n,a = 22.06(4) ?, b = 6.251(11) ?,c = 22.73(4) ?,Z = 4, final R1 = 0.0774, wR2 = 0.1406(I>2 σ(I)). And complex 1 is four-coordinated tetrahedron geometry; while complex 2 is six-coordinated distorted octahedral geometry. Spectrum data indicate that the two complexes all can intervene into DNA two-strands . Chapter two: According to literature, pyridine-3-carboxaldehyde thiosemicarbazone Ni(II),Zn(II) complexes have been synthesized. Their formulas are [Ni(C7H7N4S)2] 3,[Zn(C7H7N4S)2(H2O)2(CH3CH2OH)2](NO3)2 4. Complex 3 belongs to monoclinic system, space group P21/c,a = 5.4774(16) ?,b = 19.865(6) ?,c = 7.530(2) ?,Z = 2,R1 = 0.0303,wR2 = 0.0656(I>2 σ(I)), while complex 4 belongs to triclinic system, space group Pī,a = 8.054(3)?,b = 8.936(3) ?,c = 11.208(4) ?,Z = 1,R1 = 0.0254,wR2 = 0.0707(I>2 σ(I)). Complex 3 is four-coordinated planer quadrangle geometry, while complex 4 is six-coordinated distorted octahedral geometry. Spectrum data indicate that the two complexes all can intervene into DNA two-strands. In the same time, we have investigated the two complexes'bacterium-restraining activities, indicating complex 4 have good restraining function to coccus, while complex 4 is not so likely due to its hardy-soluble.
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