Design And Synthesis Of Novel Chiral PNA Monomer-cyclen Conjugates

Peptide nucleic acid (PNA), as mimic of DNA, is a kind of antisense nucleic acid. PNA can prevent DNA/RNA from transcription and translation by recognition and binding with the specifical sequence of DNA or RNA in organism. Nowadays, PNA and their analogues have represented express function elementarily in diagnosis and therapy of diseases. Macrocyclic polyamine is a type of unique and excellent ligand for coordinating metal ions. Macrocyclic polyamine metal complexes as enzyme models are widely used in chemical biology, medicine and gene therapy. In this thesis, a series of novel chiral PNA monomer-cyclen conjugates have been designed and synthesized. Preliminary studies on the characters of their zinc complex have been performed. Some useful results have been obtained from this study. The target compounds have been synthesized by L-cysteine hydrochloride and uracil. With this synthetic method we have successfully synthesized a series of amino acids and dipeptides that connect uracil to its special point. Their structures were identified by MS and 1HNMR.