| Nowdays, More attention has been paid to the research and development of the renewable biomass for the decrease of traditional energy and resourses and environmental pollution resulted from the use of non-biodegradable synthetic polymers. People all think only by which the society may walk in a sustainable development way. Chitosan ,sodium alginate, gelatin are natural polymers abundant in the world. And they all have the biocompatible ,nontoxity, biodegradable properties. For this reason, the utilization and development of which have become the focus in the field of new polymer materials. In this paper, The physical and chemical properties of the above three polymers, current research and recent progress of the utilization as a membrane material of chitosan and the use for controlled drug delivery of sodium alginate and gelatin were first reviewed ,then the structure and functional properties of chitosan/gelatin/Nano-Tio2 composite films ,miscibility and drug release properties of chitosan/polyethyleneglycol and gelatin/sodium alginate drug-loaded composite films was studied.The main contents and conclusions are as follows:(1) Nano-titanium particles was treated with anionic surfactant detergent SDS to prepare Cs/Gelatin/Nano-titanium dioxide composite films by solution method, the films obtained were characterized by FT-IR,XRD,SEM,TEM,oplical trasmittance,percent water absorption, the measurements of mechanical properties and antibacterial activity.It was found that there was hydrogen bonding interactions between chitosan , gelatin molecules and titanium dioxide nanoparticles.To induce gelatin into the films can increase their tensile strength in dry state and breaking elongation in wet state but decrease the tensile strength in wet state and breaking elongation in dry state, proper content of titanium dioxide nanoparticles can make up for the defectant above .and also found that the antibacterial activity of conposite films decreases with increasing gelatin content but increases with Nano-titanium particles increasing content.The film may be used as green package materials.(2)Drug loaded composite membranes was obtained by adding the drug Ciprofloxacinhydrochloride to the homogeneous blending solution of chitosan and the nontoxic,immunogenic,biocompatiblc polymer polycthylenglycol. The drug-loaded matrix and the drug-loaded film was characterized by FT-IR, XRD,SEM. the results showed there was some strong interaction and good compatibility of chitosan and PEG ,the matrix and the drug in the matrix film and the drug-loaded film respectly. The effect of parametes on the drug release rate was studied too,and the drug release rate decreased as the increment of pH value,the membrane thickness, the amout of loaded drug and decrease of the composition PEG in the matrix, Besides this , which also was infiuced by the solution concentration of the coating material sodium alginate, when the solution concentration increased ,the drug release rate decreased. This kind of drug loaded film has a promising application in the field of medical package industy.A seires of drug-loaded films were prepared by adding drug Ciprofloxacinhydrochloride to the homogeneous blending solution of gelatin, sodium alginate and a follow crosslinking precess. The stucture and miscility between the matrix compositions,drug-loaded matrix and the drug were characterized by IR,XRD, SEM. The results indicated there was some strong interaction between the matrix compositons, matrix and the drug.the influence factors to the drug release rate was then studied, and it was found the drug release rate decreased as the increase of the crosslinking degree, the membrane thickness, drug-loaded amount and sodium alginate content in the matrix. And also found that the drug release rate first decreased then increased as pH value increased froml.O to 7.0. The reason is the interation have changed between the matrix compositon. By changing the preparation parametes we can obtain drug-loaded films with different drug release rate.The films have a promising utilization in the clinical package matrials as a new drug delivery system based on natural polymers. |
