Study On Synthesis Of Aminopyridine

A general synthetic route of aminopyridines such as 2-aminopyridine, 3-aminopyridine and 4-aminopyridine, which were useful organic intermediates, was investigated. The target compounds were synthesized starting from corresponding cyanopyridines, via incompletely hydrolysis in the presence of hydrogen peroxide taking the mixture of acetone-water and dilute base as solvent, and Hoffman degradation reaction with freshly made NaBrO. This route is much of industrial value because of the cheap and easily gained materials, the moderate reaction condition, and the convenient operation.The feasible conditions of above synthetic process were also discussed. And a new compound 2-carboxamino-3-methyl-pyridine was obtained.