Study On Overheated Water Sterilization Of PDF Lipo Microsphere

Lipo microsphere is a monomolecular dispersing system. It's enveloped byphospholipid, and soybean oil inside. The average diameter of the lipo microsphere, LMis 200nm, and the average diameter of the lipo namo spheres,LN is 50nm. LM is greatdifference to oral and powder, LM have stronger drug effect, action faster, release longer.The structure of the PDF is ester, which will be decomposed at high temperature. WhenPDF is dissolved in LM, the sterilization will take great effect on LM.The ampoule specification of the PDF is 20ml/per, in order to get the wellhomogeneity and efficacy of sterilization, and reduce the decompose of PDF which willcause less content than require, overheated water sterilization will satisfy all the requires.The medium of overheated water sterilization is overheated water. The product, which ispreparing for sterilization can be sterilized and heated by overheated water By the use ofoverheated water convection, the temperature of every product can be nearly same. Thesterile quality of product is getting higher and time is getting shorter. The overheatedwater sterilization has no dead angle, but it can be happen in steam sterilization, and italso avoids contamination of cooling water. The ampoule could not explode because theampoule is heated slowly and cooling down slowly. the sterilization temperature can beadjust between 60℃～127℃ ,and the ampoule leak check can use the color water whenthe color water get inside the vacuum sterilizer.Through investigation for degradation,appearance, diameter and stability of PDFLM at different temperature , time, pH,present article determine the best sterile timeand temperature. After sterilizing, PDF LM will get the well homogeneity and efficacyand reduce the decompose of PDF to get the longer stability...