Studies On Some Organic Synthesis Reactions Catalyzed By Solid Acids

Solid acid catalysts have been found to be useful catalyst in a variety of organic reactions. They have many advantages, such as non-toxic, inodorous, non-volatile, non-corrosive, non-pollution, mild reaction conditions, high yields and reactivity, excellent stability and simple work-up procedure, and these are what liquid catalysts cant replace.Based on recent work about solid acids, some research was done. Silica sulfate has some advantages such as unique acidity, high activity, high selectivity, easy preparation and simple work-up procedure, so it may be used in reactions which can be catalyzed by acidic catalysts.An efficient and convenient approach to the synthesis of 1,1-diacetates and deprotection of 1,1-diacetates using silica sulfate as the catalyst is described. This method provides several advantages such as environment friendliness, high yields, simple work-up procedure and the catalyst is also inexpensive and reusable.A rapid and efficient method for acetylation of a series of alcohols and phenols with acetic anhydride catalyzed by silica sulfate solid acid at room temperature or at refluxing temperature in excellent yields is described.NH₂SO₃H was used to efficiently perform one-pot, three-components, Biginelli condensation reactions of aldehydes, β-ketoesters and urea under solvent-free conditions at room temperature by grinding method. The method offers several advantages including mild reaction conditions, simple experimental procedure, and environmental friendly and excellent yields.