Study On Synthesis Of Cyclopentadecanolide Catalyzed By Solide Acid From Methyl 15-Hydroxypentadecanate

Cyclopentadecanolide is an important macrocycle musk. It is widely used in perfume, cosmetic, food, and medical industry. Starting from cis-tetracos-15-enoic acid, obtained from malania oleifera oil through saponification, acidification and solvent crystallization, cyclopentadecanolide was synthesized with catalyzing by solid acid from methyl 15-hydroxypentadecanate, which obtained from cis-tetracos-15-enoic acid through several steps, such as ozonization-reductation, acidification, methyl esterification. The contents were as follows:Cyclopentadecanolide was synthesized from methyl15-hydroxypentadecanate catalyzed by solid acid had been investigated. NaY zeolite, NH₄Y zeolite, and HY zeolite all showed obviously capacity to catalyze the reaction, which was unreported.The effect of roasting temperature, roasting time, and grain size of NH₄Y zeolite on synthesis of cyclopentadecanolide from methyl 15-hydroxypentadecanate had been studied. The result demonstrated the...