Macrocyclic Polyamines With An Imidozalium Salt Group And Their Monometallic Complexes: Synthesis, Mimic Enzyme Catalysis, Their Interaction With Plasmid DNA And Fluorescence Supramolecular Recognition

Metallic Complexes of macrocyclic polyamine have many special properties, such as chemical nucleases,catalyst of DNA cleavage, fluorescence sensor of cation, small molecular sensor, biology sencer and so on. Chemical nucleases and biology sence are a new challenging field that is quickly developing in chemical biology. In this dissertation, new macrocyclic polyamines with an imidozalium salt group and their metal complexes have been designed and synthesized, mimic enzyme catalysis and fluorescence supramolecular recognition have been studied. A series of useful and creative results have been obtained. Four new types of macrocyclic polyamines containing an imidozalium salt group and their monometal (transition metal Cu(II), Zn(II), Co(II)) complexes have been designed, prepared and affirmed by IR, MS and 1HNMR spectroscopy. The synthetic methods and effect factors of the title compounds have been systematically studied. A series of convenient and efficient reactions have been developed.The novel macrocyclic polyamine 1, 4, 7, 10-tetraazacyclododecane (cyclen) monometallic complexes containing varying kmidazalium salt groups and their characterization of cleavage with plasmid DNA pUC19 are studieded herein systemlly. It is clearly that the positive charge of imidozalium salt group...