| Recent booming of nanoscience and nanotechnology directs people to a new world. As the development of nanoscience, nanoscaled materials are frequently used in biological or biomedical fields. Nanomedicine has already been a very important and individual research subject. Among numerous functional nanomaterials, near infrared (NIR) active materials are especially interesting which open a new door toward the noninvasive diagnosis and therapy.In this thesis, we focus on one class of NIR responsive nanomaterials — gold nanorods. The conventional seed-mediated growth method was repeated and experimental conditions are discussed. High quality and high yield short gold nanorods whose longitudinal band covers the whole visible and NIR region were prepared. More careful modification of the growth condition can lead to fine shape-different products, including rod like, needle like and dogbone like one-dimensional gold nanostructures. A three-step protocol for preparing long gold nanorods has also been reviewed. Novel method based on pH controlled growth strategy has been successfully developed to facile synthesize ultra-long gold nanorods.Moreover, a completely new method named surface initiated atom transfer radical polymerization (ATRP) was carefully designed to coat NIR responsive gold nanorods with uniform poly(N-isopropylacrylamide) shell. This is the first example of modifying gold nanorods with polymers via "graft-from" method. Further experiment shows these nanohybrids could response to both temperature and NIR exposition well. Phase transition temperature is in a narrow range of 32-37℃. The ability of loading big organic molecule drug like nonvancomycin and small inorganic salt like silver ion was investigated. The drug release experiment revealed a fast release behavior could be induced when exposed to higher environmental temperature or NIR radiation. This kind of NIR remote drug release property shows numerous potential in vivo applications such intelligent drug delivery system.
|
PDF Full Text Request