Synthesis And Study Of Some 5-methyl-1-aryl-4-substitutedmethyl-1H-1,2,3-triazole Derivastives

Up to now, it has been reported that 1H-1,2,3-triazoles and their derivatives are one type of compounds which have extensive biological activities by numerous literatures. They are widely used in industry, agriculture, medicine and so on. Therefore, this kind of aromatic heterocycles is getting more and more attention due to their extensively application and new compounds were synthesized constantly till now. Because of the above truth and in order to obtain new biologically active compounds, We have worked on synthesis and inquirement of some series of 1H-1,2,3-triazole derivatives in the field.1H-1,2,3-triazoles are primarily used in medicine because of their extensive biological activities. In recent years, new compounds were synthesized continually and their biological activities were determined and proved. In order to look for new biological activities, we designed and synthesized three series of compounds in this thesis. In these compounds, we introduced functional group such as imidazole and aziridine group. Moreover, we determined biological activities of two compounds in two series. All compounds' structures were determined by ~1HNMR, IR and MS. The crystalline structures of three compounds were determined by x-ray diffraction method.In this thesis, it is descripted that new twenty-seven compounds are synthesized. Ethyl 1-aryl- 5-methyl-1H-1,2,3-triazole-4-carboxylate derivatives were synthesized from aromatic amine. (1-Aryl-5-methyl-1H-1,2,3-triazol-4-yl)diarylmethanol were obtained by the reaction of ethyl 1-aryl-5-methyl-1H-1,2,3-triazole-4-carboxylate derivatives with aryl Grignard reagents. We synthesized two series of 1H-1,2,3 -triazole derivatives by two different methods. In the synthesis method and yield, the advantage and disadvantage of two methods have respectively exhibited. Besides, the structures of bis(3-chlorophenyl)(5-methyl-1-p-tolyl-1H-1,2,3-triazol- 4-yl)methanol, 5-methyl-1-phenyl-4-[diphenyl(1H-imidazol-1 -yl)methyl]-1H-1,2,3-triazole and 4-[(a ziridin-1-yl)diphenylmethyl]-5-methyl-1-p-tolyl-1H-1,2,3-triazole were determined by x-ray diffraction method. In order to look for the biological activities of compounds we synthesized, we choice 4- [bis(4-chlorophenyl)(1H-imidazol-1 -yl)methyl] -1 -(4-chlorophenyl)-5 -methyl- 1H-1,2,3-triazole and 4-[(aziridin-1 -yl)diphenylmethyl]-5-methyl-1-p-tolyl-1H-1,2, 3-triazo- le and determined their biological activities.