Synthesis And Characterization Of New Compounds Of Methane With Diaryl, Triazole And Heterocycle

Diphenylmethane derivatives are one type of compounds with biological activity,which are widely used as the medicine of antihistamine.In order to obtain new agents of biological activity,we introduce 1H-1,2,3-triazole derivatives which have the extensive biological activity and some small nitrogen heterocycles such as morpholine,aziridine,imidazole and 5-fluorouracil etc.,synthesize a series of new compounds of methane with diaryl,triazole and heterocycle.We obtained aryl azide using the aromatic amine as the starting material, which underwent the diazotization and reacted with sodium azide.The key intermediate 1-aryl-5-methyl-1H-1,2,3-triazol-4-carboxylic acid were prepared by the 1,3-dipole ring addition reaction of aryl azide and ethyl acetoacetate under the basic conditions.They underwent esterification,and then reacted with phenyl Grignard reagents to give(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-diphenylmethanol. The target compounds were synthesized by the reaction of (1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-diphenylmethanol and morpholine, aziridine,imidazole and 5-fluorouracil.All the structure of new compounds was identified by ~1HNMR,IR and MS.The crystal structures of two compounds were determined by X-ray diffraction method.In this thesis,we have synthesized fifty new compounds.These are potential application foreground in the compounds,which is the sense important so that they were researched.