Studies On Oxime Ether Containing Pyridine (Thiazole) And Alkylation Of Dihydropyrimidine

In this paper, novel oximinophosphorothioates and oxime ether derivatives are designed and synthesized by bringing the pyridine, thiazole, thiophosphorate and oxime moieties into a molecular framework according to sub-structure linkage, bioisosterism theories. Also , we designed and synthesized a type of novel double substituted dihydropyrimidine derivatives by introducing pyridine and thiazole into dihydropyrimidine molecular framework. The structures of all target compounds prepared have been confirmed by ~1H NMR, IR, EI-MS spectroscopy, elemental analysis and X-ray diffraction analysis.1 Oximinophosphorothioates containing 1H-1, 2, 3-triazole and pyridine or thiazole (â… )2. Oxime ether containing 1H-1,2,3-triazole and pyridine or thiazole (â…¡).3. Dihydropyrimidine ethanone double-substituted derivatives containing of pyridine or thiazole (â…¢) moieties. The preliminary biological activities of these target compounds showed that some of them exhibited some extents of pesticide activitiy.