Synthesis And Characterization Of Intelligent Polymer Hydrogels And Preliminary Study On Their Applications In Analytical Chemistry

Three kinds of the dual-funational N-isoprylacrylamide-co-β-Cyclodextrin Smart Hydrogels,which contain an environmental sensitivity component and a molecular inclusion function component,were systhesized.Based on their special functionalities,the smart property and the molecular inclusion ability of these hydrogels were studied,and their application prospects in analytical chemistry were discussed.This thesis consists of four chapters.In chapter one,the literature on the research and application of the intelligent polymer hydrogels,β-Cyclodextrin polymer derivatives and PAHs was summarized. The chapter first described the intelligent polymer gels to the environment sensitivity in several areas such as the solvent,temperature,pH,light radiation,the electric field, magnetic fields and so on,based on the Volume Phase Transition theory and introduced the applications of the smart polymer gels in biomedical engineering, controlling drug release,immunoassay and bioseparation analysis.Then,it described the research and applications of cyclodextrins(CDs),cyclodextrin derivatives and cyclodextrin polymer in analytical chemistry.Thirdly,the chapter summaried the properties and structures of the PAHs and overviewed the analysis of PAHs.Finally, the research objectives and considerations were proposed.In chapter two,the polymer N-isopropylacrylamide-N-allylamino-β-cyclodextrin hydrogel(ACD/PNIPAM)was synthesized and characterized.The research and applications of the interaction between the ACD/PNIPAM with pyrene in the environment analysis were discused.First of all, mono-6-deoxy-6-(p-tolylsulfonyl)-cyclodextrin(6-OTs-β-CD)was prepared.Then theβ-CD monomer,N-allylamino-modified-β-cyclodextrin(ACD),was synthesized via the reaction of 6-OTs-β-CD with allylamino.Finally,ACD/NIPAM,β-cyclodextrin smart hydrogel was synthesized through the free radical polymerization of ACD monomer with NIPAM monomer.The ACD monomer and the ACD/NIPAM copolymer hydrogel were characterized by Nuclear Magnetic Resonance(NMR), Infrared spectroscopy(IR),Mass spectrometry(MS),and so on.The interior morphology of ACD/PNIPAM copolymer hydrogel was observed by Scaning Electronic Microscopy(SEM).The characteristics of the Smart Hydrogel ACD/PNIAM on molecular recognition,separation properties and determination properties were studied by using Fluorescence Microscopy and Fluorescence spectrocopy.Interaction between the ACD/PNIPAM hydrogel with the PAHs molecules was investigated.The ACD/PNIPAM hydrogel showed a good application prospect in environmental analysis.In chapter three,the MAH-β-CD/PNIPAM copolymer hydrogel was synthesized and characterized.The temperature sensitivity and the molecular inclusion ability of the MAH-β-CD/PNIPAM hydrogel was discussed.First of all,aβ-CD based monomer,with vivyl carboxylic acid groups via reaction ofβ-CD with maleic anhydride(MAH)was prepared.Then MAH-β-CD/PNIPAM hydrogel was synthesized from the free radical-redox polymerization.The MAH-β-CD monomer and the copolymer hydrogel were characterized by Nuclear Magnetic Resonance (NMR),Infrared spectroscopy(IR)and Mass spectrometry(MS)and so on.The interior morphology of MAH-β-CD/PNIPAM copolymer hydrogel was investigated by Scaning Electronic Microscopy(SEM).By using Fluorescence Microscopy and Fluorescence spectroscopy,the characteristics of the Smart Hydrogel MAH-β-CD/PNIAM on molecular recognition,separation properties and determination properties were studied.Interaction between the MAH-β-CD/PNIPAM hydrogel with the PAHs molecules was investigated.The MAH-β-CD/PNIPAM hydrogel showed a good application prospect in analytical chemistry.In chapter four,a poly(N-isopropylacrylamide-co-acrylic acid)-6-ethanolamine-β-cyclodextrin ionic polymer(EAA-β-CD/AA/PNIPAM)was synthesized and characterized,and the temperature sensitivity and the molecular inclusion ability of the EAA-β-CD/AA/PNIPAM ionic polymer hydrogel was discussed.First of all,the poly(N-isopropylacrylamide-co-acryl acid)(poly(NIPAM-co-AA))was prepared from the polymerization of NIPAM with AA.Then,EAA-β-CD was prepared via the reaction of mono-6-OTs-β-CD with EAA.Finally,a EAA-β-CD/AA/PNIPAM smart hydrogel was synthesized by the reaction of poly(NIPAM-co-AA)with EAA-β-CD. The EAA-β-CD monomer and the ionic polymer hydrogel were characterized by Nuclear Magnetic Resonance(NMR),Infrared spectroscopy(IR)and Mass spectrometry(MS)and so on.The interior morphology of EAA-β-CD/AA/PNIPAM ionic polymer hydrogel was observed by Scaning Electronic Microscopy(SEM).By using Fluorescence Microscopy and Fluorescence spectrocopy,the characteristics of the smart ionic hydrogel EAA-β-CD/AA/PNIPAM on molecular recognition, separation properties and determination properties were studied.Interaction between the EAA-β-CD/AA/PNIPAM ionic polymer hydrogel with the object PAHs molecules was investigated.EAA-β-CD/AA/PNIPAM ionic polymer hydrogel showed a good application prospect in analytical chemistry.