The Synthesis Of 2-Mercapto-Oxide-Pyridine Sodium Salt And Research Of Antibacterial Properties

2-mercapto-oxide-pyridine sodium salt is a new kind of bactericide which has very good prospect. In this study. 2-mercapto-sodium-oxide pyridine is researched for preparation and antibacterial properties , which provided a product for medicine, paint and indoor bactericide.2-mercapto-oxide-pyridine sodium salt was synthesized by the processes of acetyl, oxidation, hydrolysis, diazotization, chlorination, sulphydryl and salification with the starting material 2-aminopyridine, and the synthetic craft was researched. The yield of oxidation was 82.5%, and the optimal temperature and reaction time of oxidation were 75℃and 3.5h respectively; the yield of hydrolysis was 87%, and the optimal temperature and reaction time of hydrolysis were 80℃and 2h respectively. When pH of solution in Sulfhydryl was 9, the yield is 85.2%. The total yield was 61% under above optimal conditions.Six kinds of indoor common bacteria——bacterial (Escherichia coli, Bacillus subtilis, White staphylococcus) and fungi (Aspergillus, Mucor, Rhizopus) was used to do qualitative tests for the antibacterial effect on 2-mercapto-oxide-pyridine sodium salt. All bacteria was inhibited at CNaPT≥1×10-3(mass%); there were significant inhibition of centrals at 10-4,10-5(mass%), which showed good antibacterial effect at low concentration. Then UV spectrophoto-meter was used to measure the minimum inhibitory concentration (MIC), and the whole MIC of six kinds of indoor common bacteria were 11mg/L, 9mg/L, 15mg/L, 9mg/L, 5mg/L, 7mg/L respectively.Experimental results showed that such compound had good antibacterial properties against common bacteria. And it has better inhibitory effect on fungi than bacteria generally. The performance broad-spectrum, highly antibacterial efficient of NaPT will lead to the extensive application in medicine and health care, anti-pesticide, paint antibacterial agent and indoor bactericide.