Microwave-Assisted Carbon-Sulfur Bond Formation And Carbonylative Annulation

Sulfides, thioacetals and 2-quinolone derivatives exhibit remarkable biological activities, which play important roles in the pharmaceuticals, agricultural chemicals and natural bioactive compounds. Therefore, the efficient synthesis of these compounds is the focus of research interests of organic chemists. In recent years, it is popular for the utilization of microwave irradiation in organic synthesis within the academic and technical arenas. In this context, we have documented a straightforward and rapid synthesis of thioacetals, sulfides and 2-quinolone derivatives under microwave irradiation.1. We have developed an efficient carbon-sulfur bond formation reaction under microwave irradiation. This reaction affords a rapid method for the synthesis of thioacetals and sulfides. Noteworthy, this method has shown its high efficiency, experimental simplicity, and no transition-metal catalyst was used in this reaction.2. The rapid and efficient synthesis of 3- and 4- substituted 2-quinolones using microwave-assisted carbonylative annulation of unprotected 2-iodoanilines and terminal alkynes has been described. Under optimal conditions, the corresponding 2-quinolones were achieved. Furthermore, we also studied the proposed mechanism about this reaction.The structures of all target compounds were characterized by ¹H NMR, ¹³C NMR, MS, and elemental analysis.