Application Of Iron Complexes Supported By Trimethylphosphine In C-Cl And C-F Bond Activation

Aromatic halides have considerable interest as herbicides,pesticides, anti-inflammatory drugs and functional dyes,because of their wide applications in the industrial,agrochemical,pharmaceutical and dye industry and so on.Therefore,the synthesis of aromatic halides play a key role for the chemical research and social development.However,the chloro and fluoroarenes exhibit much lower reactivity with reference to the great strength of their C-X bonds.Therefore,these compoundes caused increasingly serious environmental polution,for their difficulty to natural degradation.It is not surprising,that attention of numerous research groups has been focused for many years on activation and funvtionalization of the C-Cl and C-F bond.And they expected to seek new halogenation,dehalogenation and functionalization,and solve the increasingly serious environment problem.A variety of C-Cl and C-F activation reactions that employ electron-rich transition-metal complexes have been achieved.Iron belongs toâ…§family of transition metals,which has been widely used in organic synthesis,industrial catalysis,etc,for its fine coordination activity and relative low price.Especially,iron is easy to form stable complexes with compounds containing lonely electrics,since iron has a strong tendence to achieve more electronic inert gases(Kr).Teimethylphosphine coordinates with iron very strongly and forms rich low-valent complexes,due to their ability of highly coordination and fine electron donors.The organic compounds of iron coordinated with trimethylphosphine have high reaction activity and selectivity.The past research have indicated that iron complexes supporting with trimethylphosphine show excellent activity in the activation of C-H bonds belong to aromatic hydrocarbon.We synthesised the new hexa-coordinated iron-chloro complexes with imine as an anchoring group,which were formed by cyclometalation reactions involving carbon-chlorine bond activation at iron(0) or Iron(â…¡) complexes.Furthermore,we explored the functionalization of iron complexes with methyllithium,carbon monoxide,phenylchloromagnesium,and terminal alkynes.In addition,we got dichelated iron(â…¡) complex by the activation of C-F bond with oxygen of ketone carbonyl as an anchoring group.All of the now complexes are characterized by IR,¹H,¹³C and ³¹P NMR. structures of some single crystals have been confiemed by X-ray diffraction techniques.