Study On Triphosgene In The Preparation Of Aliphatic Acyl Chlorides And Acylthioureas

This thesis includes three chapters.Chapter 1: A brief review for the research in synthesis of acyl chlorides and acylthioueas in recent yearsThis chapter is a brief review for the character and synthetic methods of triphosgene,conventional synthetic methods of acyl chlorides,the application of triphosgene in the preparation of acyl chlorides in recent years,the application and synthetic methods of acylthioueas.Chapter 2: New technology studies on producing aliphatic acyl chloride using triphosgeneThree aliphatic acyl chlorides were synthesized by exploration of best reative conditions such as univariate analysis, orthog onal test, optimization design, using triphosgene as chlorinating agents. The products'purity were determined by the gas chromatography.Chapter 3: Simple synthesis, crystal structure and biological activities of N-Isononanoyl- N'-arylthioureasA series of new N-Isononanoyl-N'-arylthiourea compounds were synthesized simply rapidly and high efficiently by serial reactions of triphosgene, isononanoic acid, potassium thiocyanate and aromatic amines, under solvent-free conditions, and confirmed by IR, 1H NMR and 13C NMR spectra. The crystal structure of compound 4g was determined by X-ray single crystal diffraction analysis. The preliminary biological activity tests show that some of the title compounds have some regulating activities for the growth of rape.