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A Study On The Preparation Of NiuHuangShangQing Granules

Posted on:2011-07-02Degree:MasterType:Thesis
Country:ChinaCandidate:Y GaoFull Text:PDF
GTID:2121360305455016Subject:Pharmaceutical Engineering
Abstract/Summary:PDF Full Text Request
Artificial bezoar bezoar supernatant capsule as the main raw material scattered wind pain attending heat purging fire. For headache, dizziness, red eyes and ringing in the ears, sore throat, mouth sores, and gum swelling and pain, stool and other dry end. Is a widely used traditional Chinese medicines. However, the market circulation of bezoar supernatant formulations based on the form of pills and capsules, and that due process requirements of the original, largely reduced the supernatant preparation Niuhuang active ingredients of drug absorption. In this paper, the manufacturing process for the bezoar supernatant capsule are many problems that exist in areas from technology to improve, first of all by the orthogonal experimental program of optimization of water extraction and spray drying process, using dry method tablets, film coating method to obtain new formulations change supernatant of drug particles that bezoar. By dual wavelength TLC, high performance liquid chromatography, gas chromatography sample of the supernatant bezoar and its active ingredient particles and the borneol content of bilirubin was determined, the results confirmed that the introduction of new technology supernatant obtained particles bezoar the active ingredient content of bilirubin and significantly higher than the bezoar borneol supernatant capsules, experimental results show that the drug production process to improve the process, the use of advanced processing technology of drug film coating, which makes the performance and efficacy of drugs from both With the great changes and improvement. Therefore, application of new technologies on traditional Chinese medicine plays a key role in career development.
Keywords/Search Tags:Spray drying, thin film coating, dual-wavelength TLC-scanning method, dry method granule technology, high performance liquid chromatography, gas chromatography
PDF Full Text Request
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