Iron-catalyzed Efficient Synthesis Of The Xanthone And Acridine Derivatives

This thesis focuses on iron-catalyzed synthesis of xanthones and acridines via C-C bond formation reactions. Iron-catalyzed reactions have drawn much attention in organic chemistry. Iron compounds are usually low price, easy to synthesize and environmentally friendly, compared to other metals, such as gold, silver, palladium, etc. Recently, excellent works of iron-catalyzed C-N, C-O, C-S, C-C cross-coupling reactions have been reported.There are two parts in this thesis. In part one, iron-catalyzed synthesis of the xanthones skeleton from 2-phenoxybenzaldehydes with DDQ as an oxidant was reported.11 designed xanthone derivatives were synthesized with the yields from 40% to 94%. All the compounds were characterized by 1H and 13C NMR spectroscopy or MS.In part two, iron-catalyzed synthesis of acridine derivatives from 2-(phenylamino) benzaldehyde derivatives was developed. The 2-(phenylamino)benzaldehyde derivat-ives reacted smoothly in the presence of 0.1equiv of FeCl3 and 0.2equiv of morpholine, Five designed derivatives were synthesized with the yields from 83% to 94%. All the compounds were characterized by 1H and 13C NMR spectroscopy or MS.