Iron-catalyzed arylation of heterocycles and transition-metal free C-N bond formation |
Posted on:2016-11-04 | Degree:Ph.D | Type:Thesis |
University:University of Rhode Island | Candidate:Sirois, John Joseph | Full Text:PDF |
GTID:2471390017978998 | Subject:Organic Chemistry |
Abstract/Summary: | |
The formation of carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds is discussed and efforts towards expanding the known reactions of this type are the primary focus of this work. The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes and furans has been achieved. The use of an imine directing group allowed for the ortho-functionalization of these heterocycles with complete conversion in 15 minutes at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls. C-N bond formation is achieved using aryl Grignard reagents and N-chloroamines at -78 °C. |
Keywords/Search Tags: | C-N bond formation, Iron-catalyzed arylation, Heterocycles |
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