Studies On Structures And Biological Activities Of Complexes With Flexible Open-chain Ligands

The flexible open-chain ligands with N, O, or S heteroatoms, which have strong coordination abilities and flexible binding modes with metal ions are one of the most important parts of the studies on supramolecular chemistry. This work studied the self-assembly of supramolecules, as well as controlled design strategies of functional coordination compounds through investigations of the crystal structures and properties of supramolecular complexes with series of flexible open-chain ligands. Furthermore, the biological activities and applications of some coordination compounds have also been preliminarily studied.1. A brief introduction of supramolecular coordination chemistry of the status of basic and applied research. And the aim as well as the progress of this work have been outlined.2. Two flexible open-chain ligands with the alkyl chain containing O heteroatoms connected 2-mercaptopyridine were designed and synthesized. The influence of length of alkyl chain on the supramolecular structure built was studied through the crystal diffraction analysis of complexes of Cu(II) or Ag(I).3. With the alkyl chain containing O as backbone group, and 2-mercaptobenzothiazole as terminal group, two flexible open-chain ligands were synthesised together with their complexes of Cu(II) or Ag(I). The influence of terminal groups on the supramolecular structure built has been explored by comparing the crystal structure between this part and last part.4. We synthesized two flexible tripodal ligands based on the bridged N atoms as centers. The influence of backbone on the supramolecular construction was discussed by investigating the structures and properties of these complexes.5. The nano-particle suspension was prepared by using the obtained complexes and the phaeodactylum algae growth inhibition activities were tested. The relationship between the coordination structures and biological activities was discussed.