A Novel And Efficient Method For The Synthesis Of 1H-indol-3-yl Acetates

The thesis consists of two parts:The first part is summation, which consists of there chapters. The first chapter mainly introduces the application of indole and its derivatives which is one of the most important compounds in organic synthesis. Indole and its derivatives are extensively existence in nature. It can be used in medicinal, chemical industry and so on. Their value goes without saying that. The second chapter mainly introduces the application of (diacetoxyiodo)benzene which is one of typical hypervalent compounds in organic synthesis. The organic chemistry of polyvalent iodine compounds has experienced an unprecedented, explosive development in recent years. Because polyvalent iodine compounds resemble the reactivity characteristics of Hg(â…¡), Tl(â…¢), and Pb(â…£) cognates without the toxic and environmental problems associated with the heavy metal species. The chapter is to summarize the progress of polyvalent iodine compounds in organic synthetic reaction such as oxidation, addition, substitution and rearrangement in recent ten years.The second part is our works about the improvement in 3-substitute position acetoxylation of indoles. Our reaction was performed in alkaline and approached room temperature, using indole and (diacetoxyiodo)benzene as raw materials, just in a short time to achieve our objective. In this reaction, (diacetoxyiodo)benzene is used both as raw material, and as oxidant. This method for the synthesis of indol-3-yl acetates was without parallel in history.