The Synthesis Of Benzimidazole Derivatives

Benzimidazoles are important intermediates with good biological and pharmacological properties in organic synthesis. Because of the vital role in biological fields such as anticancer, antimicrobial, antiviral and antispasmodic activities, the research for the synthesis of benzimidazole derivatives has drawn much attention in recent years.Ultrasound has been widely used in organic synthesis. We have reported a new method of the synthesis of 2-substituted benzimidazoles catalyzed by NH4OAc under ultrasound. Compared with conventional methods, the procedures described are easy handing, environmentlly compatible, shorter reaction time and higher yield.Catalysts and reagents supported on inorganic substrates have received increasing attention in recent years as a means to develop more convenient or selective catalysts or reagents. Herein, a new method of the synthesis of 2-phenyl-1H-benzimidazole catalyzed by FeCl3/inorganic substrates was studied, improving the procedure of synthesis of 2-substituted benzimidazoles. The reaction characterized by milder conditions, shorter reaction time, higher yield, good selectivity and involvement of no toxic and expensive catalyst.Benzimidazole and their chalcone derivatives play a vital role in pharmaceutical research and exhibit various pharmacological activities like antimicrobial, analgesic, anti-inflammatory, anticancer activity. Some benzimidazolyl chalcones were designed and synthesized from 4-(1H-benzo[d]imidazol-2-yl)benzenamine with substituted cinnamoyl chlorides. This paper provides an efficient approach for benzimidazolyl chalcones.