Synthesis Of 1, 4-Dihydropyridines And These Complexes

1,4-Dihydropyridines, are a class of important biologically active compounds, which have wide prospect in the filed of medicine and biology etc. How to improve its synthetic methods and synthesize new 1,4-dihydropyridine derivatives have become the topic which the chemists and the medicine scientists widely pays attention to. Based on the reported ultrasound and solvent-free in organic synthesis including there methods, we use these approach in synthesis of 1,4-dihydropyridines and synthesize 1,4-dihydropyridines platinum, palladium complexes. We present some results as follows:The condensation of aldehydes, ethyl acetoacetate and ammonium acetate result 1,4-dihydropyridines in 80-99% yields under ultrasound irradiation without solvent and catalyst at room temperature. Compared with conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields.A rang of 2,6-dipyridinyl-1,4-dihydropyridines have been prepared in 46-88% yields within 1.5-2.5 h by the condensation of aldehydes, ethyl nicotinoylacetate and ammonium acetate in solvent-free condition without catalyst via Hantzsch reaction, whereas these 2,6-dipyridinyl-1,4-dihydropyridines was obtained in 40-81% within 4-7 h in the presence of ethanol at refluxed temperature. This method provides several advantages such as environment friendliness, high yields, simple work-up procedure.Some 1,4-dihydropyridines platinum, palladium complexes and terpyridines palladium complexes have been prepared and characterized. We have already detected anti-tumor activity to HCT-8 cell and Hela cell of these complexes in vitro. The test date show that 1,4-dihydro-4-(3-nitrophenyl)-2,6-dipyridinyl-3,5-bis(ethoxycarbonyl) pyridine on HCT-8 cell has a certain degree of inhibition, other complexes on HCT-8 cell have no significant inhibiton and all complexes on Hela cell have no significant inhibiton.