Research For Non-invasive Optical Measurement Technique For Human Blood Glucose Concentration

The blood glucose concentration is one important criterion to evaluate human healthiness, unbalanced blood glucose concentration would be dangerous for human life. At present, minimal invasive measurement is the main method for blood glucose testing. Non-invasive blood glucose research is an internationally hotspot for the lack of a precise non-invasive instrument for measurement. Near infrared spectrum is one of the measurement theory of non-invasive blood glucose, but almost all methods are not ideal in the procession of research. It is important to find a better theory for none-invasive measurement. We have done some experiments to explore some ideal theory for non-invasive blood glucose measurement.Some fundamental principle and some practical results about non-invasive blood glucose measurement have been found through the analysis of fluorescence spectrum, near infrared spectrum and photo-acoustic spectroscopy experiments.The main work and innovation of this paper is:1. Based on fluorescence spectrum, the characteristic wavelength has been discussed. Fluorescence spectra of glucose, whole blood, serum and erythrocyte corresponding to different concentration were measured. The characteristic peak position of blood glucose in the blood fluorescence spectrum was found, and the model for the intensity of fluorescence characteristic peak varies with the concentration of blood glucose was built.2. Based on near infrared spectrum law, near infrared spectra of glucose, serum and erythrocyte were measured, and the characteristic peak position of blood glucose in the blood photo-acoustic spectrum was found.3. Based on photo-acoustic spectroscopy law, fluorescence spectra of glucose, whole blood, serum and erythrocyte were measured. The characteristic peak position of blood glucose in the blood photo-acoustic spectrum and the relation between the intensity of photo-acoustic characteristic peak with the concentration of blood glucose were found.4. Owing to the analysis of three kinds of experiments, testing technology and applied foreground, etc., a conclusion is drawn that photo-acoustic spectrum theory has more development foreground in non-invasive blood glucose measurement for its advantages in depth of penetrate, sensitivity and mini-device.