Development And Application Research For In Vivo And Real-time Mini-invasive Monitoring System Of Tissue Parameters

Mini-invasive measurement of biomaterial parameters is an important research branch of tissue optics and measurement system is basic tool for research. This paper focus on the development of real-time and in vivo measurement system for biomaterial optical parameters, blood-oxygen parameters and hemodynamic parameters, this work will afford a kind of practical tool to study tissue parameters eventually.The measurement system is composed of hardware section and software section. The hardware includes stepper control system and data acquisition system. The stepper control system consists of motion controller,stepper power driver as well as stepper. The data acquisition of optical signals of biomaterial tissue contains fiber optical spectrometer, fiber probe and halogen illuminant. The software development of the measurement system is based on LabVIEW which is virtual instrument platform of the NI and it is available to realize real-time and in vivo data acquisition, storage and display. The motion controller transmits control signals to stepper power driver as soon as it receives instructions sent by the host computer, and then the driver converts the control signals into electric signals so as to drive the stepper. The scattering and reflecting optical signals from biomaterial are acquired while the optical fiber probe is stepping automatically into the tissue by the control system, and the collected optical signals are converted into electric signals through fiber optical spectrometer and transferred to the PC through the USB port to be processed further.There are some innovative points of this paper. Firstly, the measurement system developed in this paper can realize to measure eight parameters such as optical parameters, blood-oxygen parameters, and homodynamic parameters simultaneously. Secondly the reduced scattering coefficient of puncture tracks of SD rats has been studied by this measurement system and the rules of the reduced scattering coefficient about rats' brain tissues changing with the depth alteration are available through the studies. Furthermore, the change rules between normal and tumor tissue parameters of rats' brain tissues can be obtained with the researches on parameters about the C6/SD rats' brain tissues acquired through the measurement system.The measurement system has excellent stability and reliability. It is an important research platform for operation navigation, real-time and in vivo monitoring of brain surgical, early identification and diagnosis about some tumors as well. Therefore, the system has wonderful practical application value and development value.