The Research Of Ultrasonic Trig Control Technology And Device Based On Drug Site-specific Release System

With a accelerated pace of life in these days, gastrointestinal diseases become more common and recurring gradually, seriously impacting people's health and daily life. At present, gastrointestinal chronic diseases are mostly cured through long-time treatment. However, as the drug stays inside human body for an insufficient time, or as degradation occurs in the affection of gastric acid in the stomach, only small part, or even none of the drug can probably reach lesion site, and the expected efficacy is weakened or eliminated. On the other hand, according to statistics, about 40% of candidate new drug is abandoned not because of its poor efficacy on human body, but because of defective method in early animal experiments. Absorption characteristics of the drug in different gastrointestinal tract cannot be reflected accurately. Thus, the key to this research is how to increase the drug absorption at certain sites to improve local treatment.In recent years, the rapid expansion of Gastrointestinal Drug Site-specific Release Technology (GDSRT) in biological and medical areas, has provided an effective solution to the precious problem. GDSRT has a fair large scale globally. The equipment of GDSRT generally contains two parts: one is Gastrointestinal Drug Site-specific Release Capsule (GDSRC), which works inside human gastrointestinal tract with position unit, release drug trigger controling drive, driving unit and drug carrier; the other is auxiliary equipment outside the body, providing accurate and reliable technology to locate GDSRC inside the gastrointestinal tract and release the drug. GDSRT mainly contains three technologies: positioning technology in human gastrointestinal tract, trigger controlling technology and driving technology to release drug. With the financial aid from Guangdong science and technology research project (No. 2006B12901001), this thesis has completed works as bellow:First, based on the present research state both at home and abroad, on the early stage of the project, internal structure of the―Drug Delivery Device of Pneumatic Gastrointestinal Microcapsule with a Gas Pressure by Chemical Reaction based on the Technology of Ultrasonic Springing‖(hereinafter referred to as capsule) is optimized. Optimization includes: quantitative calculation and ratio optimization of the two reagents in the chemistry reaction cabin, to optimize the structure of drug reaction cabin; optimization of the drug storage cabin, to increase the carrying weight of the drug; replacement of interference fits, to get better sealing performance; etc.Second, portable ultrasonic generator is researched, which is special equipment for the capsule in this project. Through the study of ultrasonic principle and high-frequency oscillating circuits, ultrasonic transmitter circuit is designed, calculated, simulated, manufactured, tested, improved, remanufactured, and retested. And a ultrasonic generator with ultrasonic frequency and power adjustment is designed, as well as its portable shell.Last, animal experiment is carried out with portable ultrasonic generator and optimized capsule, to testify the feasibility of the principle of capsule and the reliability and practicality of the portable ultrasonic generator.Innovation of this thesis is as below: interference fits are adopted to increase the sealing of the capsule, and the parks of the capsule is optimized; the chemistry reaction cabin and drug storage cabin are improved to increase the carrying weight of the drug and decrease the time to release it; a special portable ultrasonic generator for the capsule in this project developed to expand its use; animal experiment is carried out to ensure the reliability of this invention.