Studies On The Effects And Action Mechanism Of Cysteamine On The Growth In Pigs

The tests studied the effects of two types of cysteamine-premix ( I, II) on the growth performance and blood biochemical parameters in piglets and the effects of cysteamine-premix of type II on the apparent digestibility and metabolism of main nutrients in growing pigs .1 Effect of cysteamine on the growth performance and blood biochemical parameters in piglets45 Landrace X Yorkshire piglets at the average body weight of 11.71 kg were divided randomly into 3 groups (Group A,B,C) in which there were 3 replicates each and 5 piglets in every replicates . Group A which was the control group were fed on the basic ration ,while group B and C which were the experiment groups were fed on two types of basic ration added with two types of cysteamine-premix (I, II) respectively , the dosage both were 400mg/kg(Effective dosage :120 mg/kg ) ration .The results indicated : in comparison with the control, the average daily gain of group B and C increased by 9.40% (P<0.05) , 13.17% (P<0.05) respectively ,feed conversion efficiency increased by 5.75% , 8.85% respectively , average daily feed intake both increased by 3% , diarrhea rate decreased by 43.84% , 55.86% respectively ; AKP activity of group B and C increased by 21.31% , 31.54% respectively , LDH activity of group B and C increased by 14.19% , 15.90% , GPT activity increased by 18.08% , 3.99% respectively , GOT activity decreased by 41.27%(p<0.05), 26.95% respectively ; TP concentration of group B and C decreased by 36.47% (p<0.05 ) , 27.33% (p<0.05) respectively , ALB concentration decreased by 50.08% (p<0.01) , 40% (p<0.01) respectively ,GLOB concentration decreased by 26.52% , 18.17% respectively ; the serum urea nitrogen concentration of group B and C decreased by 3.44% , 9.73% respectively , cholesterin concentration decreased by 11.08% , 44.78% (p<0.01) respectively ; SS level of group B and C decreased by 35.62% (p<0.01) , 40.08% (p<0.01) respectively ; GH level increased by 127.61%(p<0.01) , 166.69% (p<0.01) respectively , T3level increased by 6.72% , 9.91%(p<0.01) respectively, T4 level increased by 8.74% (p<0.05 ), 7.32% respectively . In this test, CS had no effects on the secretion of INS , the INS level of group A, B , C was 30.733 + 9.499uIU/ml , 30.960 + 14.989uIU/ml , 28.502 + 6.863uIU/ml respectively.2 Effect of cysteamine on the digestibility and metabolism ofnutrients in growing pigs6 Landrace X Yorkshire castrated male pigs at the body weight of about 50 kg were divided randomly into 2 groups (One was the control , the other was the experiment) , and there were 3 pigs each group . The control were fed on the basic ration , and the experiment were fed on the basic ration added with cysteamine-premix( II) , the dosage was 750mg/kg(Effective dosage was 225mg/kg) ration . The results indicated : the apparent digestibility and metabolism of the main nutrients of the experiment were higher than that of the control. Apparent digestibility of CP , GE , Ca and P increased by 2.18% (p<0.01) , 2.65% (p<0.05) , 15.47% (p<0.05) and 13.50% (p<0.05) respectively ; apparent metabolism of nitrogen , energy , Ca and P increased by 33.74% ( p<0.01), 4.57% ( p<0.01), 33.65% ( p<0.01) and 15.47% (p<0.05) respectively.The results of the two tests suggested that CS can deplete SS and increase the content of GH , T3 , T4 in serum of pigs, thereby accelerated the apparent digestibility and metabolism of nutrients in pigs . At the same time , CS increased the activity of the LDH , AKP , GPT, but it decreased the activity of the GOT and the content of the TP, ALB , GLOB in the serum of pigs . CS enhanced feed intake , decreased diarrhea and increased growth performance of pigs . There was another conclusion : the effects of cysteamine-premix of type lion the growth performance was better than that of the cysteamine-premix of type I in pigs .