| Purpose: The aim of this study was to learn the clinical characteristics and pathological changes of the main tissues and organs in natural cases and experimentally infected cases by jaagsiekte sheep retrovirus(JSRV). It provided basis of theory for understanding pathogenesis of SPA and for the clinical diagnosis. Material and method: Two natural cases of SPA in Inner Mongolia, four experimentally infected cases and four control cases of sheep were used in this study. By isolating the two natural cases till death, clinical examination, autopsy, pathohistological and ultrastructural examination were carried out. Four newborn lambs(within 24 hours after birth) were inoculated intratracheally with cell-free filtration of pulmonary tumour tissue(0.3ml/per lamb) containing SPAV-NM strain from naturally cases. Eighteen-months later, the four experimentally cases were killed and the pathological changes were examined. Results: Pathologic characteristics were found in the two natural cases. Abundant serous mucus were discharged from the sick sheep nostrils. Nodular tumors were found in lungs. Tumor cells were transformed from typeâ…¡pneumocytes. The animal temprature was almost normal. Rate of pulse and respiration were both increased, immune function was lower. RBC was damaged and its life span became short. Four experimentally infected cases appeared in the early stage of SPA. Some nodular tumors were found in the lungs. Tumour cells were transformed from typeâ…¡pneumocytes. The respiration rate was higher than that of the control. The immune function was lower, too. RBC was damaged in some degrees, its span became short. Conclusion: Forming adenoma in the lung was the main pathologic feature of SPA. Tumor cells were transformed from typeâ…¡pneumocytes mainly. The immune function was lower. The secondary infection could happen easily. In the procedure of SPA, RBC was damaged, the life span became short. The relationship between SPA and damaged RBC was worth studing further. |
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